Results 1 to 10 of about 317,262 (235)

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

Cancer Cell, 2017
CARLOS López-García, Enric Domingo, Nicholas Mcgranahan   +2 more
exaly  

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases

Cell Death and Differentiation, 1997
Shinji Kamada, Yoshihide Tsujimoto, Yoshihide Tsujimoto   +2 more
exaly  

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

European Journal of Immunology, 2015
Paul J Baker, Dave Boucher, Damien Bierschenk   +2 more
exaly  

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease [PDF]

Frontiers in Pharmacology, 2022
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production.
Aoife P. Smith, Emma M. Creagh
doaj   +4 more sources

A Fluorescence-Polarization-Based Lipopolysaccharide–Caspase-4 Interaction Assay for the Development of Inhibitors [PDF]

Molecules, 2022
Recognition of intracellular lipopolysaccharide (LPS) by Caspase-4 (Casp-4) is critical for host defense against Gram-negative pathogens. LPS binds to the N-terminal caspase activation and recruitment domain (CARD) of procaspase-4, leading to auto ...
Jinsu An, So Yeon Kim, Eun Gyeong Yang, Hak Suk Chung   +3 more
doaj   +4 more sources

Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 [PDF]

mBio
Pyroptosis is an inflammatory cell death pathway that is a key defense mechanism of intestinal epithelial cells. To successfully establish an infection, intracytosolic gram-negative pathogens must block this host response.
Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan M. Karr, Michele E. Muscolo, Lisa Goers, Truelian Yu, Tera C. Levin, Jonathan N. Pruneda, Cammie F. Lesser   +8 more
doaj   +5 more sources

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 [PDF]

The EMBO Journal
Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 functions, as well as their ...
Malvina Pizzuto, Mercedes Monteleone, Sabrina Sofia Burgener, Jakub Began, Melan Kurera, Jing Rong Chia, Emmanuelle Frampton, Joanna Crawford, Monalisa Oliveira, Kirsten M Kenney, Jared R Coombs, Masahiro Yamamoto, Si Ming Man, Petr Broz, Pablo Pelegrin, Kate Schroder   +15 more
doaj   +6 more sources

Extracellular Lipopolysaccharide Triggers the Release of Unconjugated Interferon-Stimulated Gene 15 (ISG15) Protein from Macrophages via Type-I Interferon/Caspase-4/Gasdermin-D Pathway [PDF]

Pathogens
Interferon-stimulated gene 15 (ISG15) is an interferon-induced ubiquitin-like protein that plays an important role in antiviral defense and inflammatory responses, primarily through the process of ISGylation, whereby ISG15 is covalently conjugated to ...
Sudiksha Pandit, Lindsay Grace Miller, Indira Mohanty, Santanu Bose   +3 more
doaj   +2 more sources

Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme [PDF]

Life Science Alliance, 2023
The noncanonical inflammasome generates p32/p9 and p34/p9 active caspase-4 species via dimerisation and autocleavage; both species cleave GSDMD to induce pyroptosis, whereas p34/p9 matures IL-1β.
Amy H Chan, Sabrina S Burgener, Kassandra Vezyrgiannis, Xiaohui Wang, Jadie Acklam, Jessica B Von Pein, Malvina Pizzuto, Larisa I Labzin, Dave Boucher, Kate Schroder   +9 more
doaj   +2 more sources

The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to Aggregatibacter actinomycetemcomitans Infection [PDF]

Pathogens
Periodontitis is a chronic inflammatory disease characterized by bacterial infection and immune dysregulation. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a key pathogen linked to disease progression.
Kartheyaene Jayaprakash Demirel, Alessandra Neves Guimaraes, Isak Demirel   +2 more
doaj   +2 more sources