Results 1 to 10 of about 316,317 (153)

Caspase-5: Structure, Pro-Inflammatory Activity and Evolution [PDF]

Biomolecules
Caspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
doaj   +4 more sources

The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage [PDF]

Frontiers in Immunology, 2023
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis.
Mohamed Ghait, Shivalee N. Duduskar, Michael Rooney, Michael Rooney, Norman Häfner, Laura Reng, Bianca Göhrig, Philipp A. Reuken, Frank Bloos, Michael Bauer, Michael Bauer, Christoph Sponholz, Tony Bruns, Tony Bruns, Ignacio Rubio, Ignacio Rubio   +15 more
doaj   +5 more sources

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation. [PDF]

PLoS ONE, 2017
IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.
Stephanie Zwicker, Eva Hattinger, Daniela Bureik, Aleksandra Batycka-Baran, Andreas Schmidt, Peter-Arne Gerber, Simon Rothenfusser, Michel Gilliet, Thomas Ruzicka, Ronald Wolf   +9 more
doaj   +8 more sources

Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 [PDF]

mBio
Pyroptosis is an inflammatory cell death pathway that is a key defense mechanism of intestinal epithelial cells. To successfully establish an infection, intracytosolic gram-negative pathogens must block this host response.
Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan M. Karr, Michele E. Muscolo, Lisa Goers, Truelian Yu, Tera C. Levin, Jonathan N. Pruneda, Cammie F. Lesser   +8 more
doaj   +5 more sources

Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome. [PDF]

Geroscience, 2023
AbstractA progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype ...
Hisama FM, Pillai RK, Sidorova J, Patterson K, Gokingco C, Yacobi-Bach M, Oshima J.   +6 more
europepmc   +3 more sources

SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. [PDF]

EMBO J, 2021
Endosomes are important cellular compartments for sorting internalized cargo and immune sensing. In this issue, Wang et al describe a novel signaling pathway induced by endocytosed bacterial outer membrane vesicles, where sorting nexin 10 and caspase-5 act at the endosome to promote cytosolic exposure of LPS and initiate signaling to alter epithelial ...
Dickinson MS, Coers J.
europepmc   +3 more sources

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. [PDF]

J Immunol, 2021
Abstract Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in the inflammatory activation of monocytes, macrophages, and the endothelium.
Bolívar BE, Brown-Suedel AN, Rohrman BA, Charendoff CI, Yazdani V, Belcher JD, Vercellotti GM, Flanagan JM, Bouchier-Hayes L.   +8 more
europepmc   +4 more sources

SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. [PDF]

EMBO J, 2021
Altered intestinal microbial composition promotes intestinal barrier dysfunction and triggers the initiation and recurrence of inflammatory bowel disease (IBD). Current treatments for IBD are focused on control of inflammation rather than on maintaining intestinal epithelial barrier function.
Wang X, Ni J, You Y, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H, Shen W, Shen X.   +13 more
europepmc   +3 more sources

Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis. [PDF]

Bioengineered, 2022
Circular RNA (circRNA) plays a regulatory role in periodontitis. This study explored whether circ_0138959 affected lipopolysaccharide (LPS)-induced pyroptosis in human gingival fibroblasts (HGFs). The periodontal ligament (PDL) tissues and HGFs were derived from patients with periodontitis and healthy volunteers.
Pan J, Zhao L, Liu J, Wang G.
europepmc   +4 more sources

TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury. [PDF]

Cell Death Discov, 2022
AbstractAcute kidney injury (AKI) is characterized by necroinflammation formed by necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory cells and can be activated and polarized into proinflammatory macrophages. Membranous Toll-like receptors (TLRs) can cooperate with intracellular
Liu C, Shen Y, Huang L, Wang J.
europepmc   +4 more sources