Results 21 to 30 of about 8,801,929 (295)
ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation
Frontiers in Oncology, 2021 Osteosarcoma is the most common malignant bone tumor. Chloride (Cl−) channels-mediated Cl− movement plays an important role in regulating the functions of various cancer cells, but its role in osteosarcoma remains unclear.
Fei Peng +3 more
doaj +1 more source
Antitumor activity of flavonoids from hance on gastric cancer
European Journal of Inflammation, 2021 Introduction: To investigate antitumor activity and mechanism of flavonoids from Alpinia officinarum Hance against gastric cancer. Methods: Transplanted mouse fore-stomach carcinoma (MFC) tumor mice were divided into six groups: control group, model ...
Mirensha Yakufu +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background:Sophora flavescens aiton (SFA) and its main bioactive metabolite matrine are widely used in traditional Chinese medicine (TCM) preparations and have achieved good curative effects for the treatment of various tumors.
Huan-Fu Hu +8 more
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Caspase-1 activation with concomitant degradation of cullin-1/5.
, 2021 (A)THP-1 macrophages were incubated with Eh (10:1 ratio) for increasing time (5 to 30 min) and or /with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio ...
Kris Chadee (249039) +4 more
core +1 more source
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
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Caspase-4 and -5 expression in HIOs and inhibition.
, 2022 A. Western blot measuring Caspase-4 levels in HIO lysates microinjected with PBS or STM. Blot was probed for Actin as a loading control. B. Western blot measuring Caspase-5 levels in HIO lysates that were microinjected with PBS or STM. Lysates from human
David R. Hill (2330602) +13 more
core +1 more source
Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5.
, 2021 (A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039) +4 more
core +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
core +1 more source
Mitochonic acid 5 regulates mitofusin 2 to protect microglia
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +1 more source
Biomolecules, 2022 The study was to investigate the effect of canonical and noncanonical pyroptosis in apical periodontitis. Proteins’ profiles of human apical periodontitis tissue were analyzed by label-free proteomics.
Zhiwu Wu +7 more
doaj +1 more source