Results 11 to 20 of about 8,801,929 (295)
Identification of specific tethered inhibitors for caspase-5. [PDF]
Chem Biol Drug Des, 2012 The development of highly selective small molecule inhibitors for individual caspases, a class of cysteine‐dependent aspartate‐specific proteases, has been challenging due to conservation of the active site. Previously, we discovered an allosteric site at the dimer interface of caspases‐3, ‐7, and ‐1 using disulfide trapping.
Gao J, Wells JA.
europepmc +4 more sources
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases [PDF]
Cell Death and Differentiation, 1997 Proteases of the caspase family are implicated in mammalian apoptosis and constitute a protease cascade. We characterized caspase-4 (TX/ICH-2/ICErelII) and caspase-5 (ICErelIII/TY), which are most closely related to caspase-1 (ICE) among the caspase family.
Shinji Kamada +2 more
exaly +3 more sources
Frontiers in Immunology, 2023 IntroductionHuman adenovirus (HAdV) is a common respiratory virus, which can lead to severe pneumonia in children and immunocompromised persons, and canonical inflammasomes are reported to be involved in anti-HAdV defense.
Lexi Li +9 more
doaj +1 more source
Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease
Frontiers in Pharmacology, 2022 Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production.
Aoife P. Smith, Emma M. Creagh
doaj +1 more source
Cells, 2022 Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation in ...
Ricardo Ferrari +14 more
doaj +1 more source
Anticancer Effect of Fluorouracil and Gum-Based Cerium Oxide Nanoparticles on Human Malignant Colon Carcinoma Cell Line (Caco2) [PDF]
Cell Journal, 2023 Objective: We investigated whether co-incubation of 5-FU and gum-based cerium oxide nanoparticles (CeO2 NPs) would improve half-maximal inhibitory concentration (IC50) and apoptosis in the Caco-2 cancer cell lineMaterials and Methods: In this ...
Zahra Keramati +3 more
doaj +1 more source
Increased expression of caspase 1 during active phase of connective tissue disease [PDF]
PeerJ, 2019 Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai +4 more
doaj +2 more sources
Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
Journal of Neuroinflammation, 2022 Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj +1 more source
Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin [PDF]
Journal of Investigative Dermatology, 2011 The inflammasome is a cytosolic multiprotein complex with two major functions: recognizing pathogen-associated molecular patterns and reacting to these through activation of the proinflammatory cytokines IL-1β and IL-18. In this study, we characterized the expression of inflammasome components in psoriatic skin and other common inflammatory skin ...
Salskov-Iversen, Maria L +3 more
openaire +3 more sources
Concerted Antigen Processing of a Short Viral Antigen by Human Caspase-5 and -10 [PDF]
Journal of Biological Chemistry, 2011 The generation of peptides presented by MHC class I molecules requires the proteolytic activity of the proteasome and/or other peptidases. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8(+) T lymphocytes.
Lopez, Daniel +3 more
openaire +4 more sources