Results 51 to 60 of about 11,510,202 (303)

Antimelanoma activities of chimeric thiazole–androstenone derivatives

Royal Society Open Science, 2021
The discovery of chimeric anti-melanoma agents is reported. These molecules are potent growth suppressors of melanoma cells in vitro with growth inhibition of 50% (GI50) values as low as 1.32 µM.
Steven A. Chambers, Mathew Newman, Melissa M. Frangie, Alena V. Savenka, Alexei. G. Basnakian, Mohammad A. Alam   +5 more
doaj   +1 more source

Patterns of genomic instability in gastric cancer: clinical implications and perspectives. [PDF]

, 2007
In gastric cancer (GC) the loss of genomic stability represents a key molecular step that occurs early in the carcinogenesis process and creates a permissive environment for the accumulation of genetic and epigenetic alterations in tumor suppressor genes
AGNESE, Valentina, BAZAN, Viviana, COLUCCI G, FALCHETTI M, LUPI R, OTTINI L, RIZZOLO P, RUSSO, Antonio   +7 more
core   +1 more source

Targeting potassium channels and autophagy to defeat chemoresistance

Molecular & Cellular Oncology, 2020
Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant ...
Giulia Petroni
doaj   +1 more source

Identification and Functional Analysis of Apoptotic Protease Activating Factor-1 (Apaf-1) from Spodoptera litura

Insects, 2021
Apoptotic protease activating factor-1 (Apaf-1) is an adaptor molecule, essential for activating initiator caspase and downstream effector caspases, which directly cause apoptosis.
Haihao Ma, Xiumei Yan, Lin Yan, Jingyan Zhao, Jiping Song, Rong Peng, Yongbo Yang, Jianxin Peng, Kaiyu Liu   +8 more
doaj   +1 more source

Zinc Protects against MDMA-Induced Apoptosis of Sertoli Cells in Mouse via Attenuation of Caspase-3 [PDF]

International Journal of Fertility and Sterility, 2020
Background: 3,4-Methylenedioxymethamphetamine (MDMA) disrupts function of the endocrine system and differentorgans such as heart, blood vessels, kidney, liver and nervous systems.
Nadia Hossein-Zadeh, Morteza Bagheri, Isa Abdi Rad, Marziyeh Lozeie, Mahdieh Nasir-Zadeh   +4 more
doaj   +1 more source

Deciphering the complex signalling systems that regulate intestinal epithelial cell death processes and shedding [PDF]

, 2017
Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Agace, Albert, Anon, Arnold, Assi, Barker, Begnaud, Boehm, Brand, Brugués, Capaldo, Chen, Cheung, Du, Dunn, Dürer, Edelblum, Eisenhoffer, Elmore, Ericsson, Farooqui, George, Gilbert, Gu, Guan, Gudipaty, Günther, Günther, Günther, Heller, Hodge, Hughes, Kaemmerer, Kiesslich, Kim, Kocgozlu, Koch, Kofoed, Kuipers, Kumar, Le, Lhocine, Lindemans, Marchiando, Melendez, Nava, Niculescu, Parker, Patnaik, Pentecost, Pentecost, Peterson, Pruteanu, Rankin, Rauch, Ravasio, Sagulenko, Sellin, Smith, Solaymani-Mohammadi, Taylor, Ubelmann, Van Itallie, VanDussen, Wang, Wang, Wang, Watson, Williams, Wong   +69 more
core   +2 more sources

Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol [PDF]

, 2014
The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease, and have also been associated with longevity.
Borecki, Ingrid B, Christensen, Kaare, Feitosa, Mary F, Kammerer, Candace M, Kraja, Aldi T, Lee, Joseph H, Newman, Anne B, Province, Michael A, Straka, Robert, Wojczynski, Mary K   +9 more
core   +3 more sources

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

Garcinielliptone G from Garcinia subelliptica Induces Apoptosis in Acute Leukemia Cells

Molecules, 2021
Cytotoxicity and apoptosis-inducing properties of compounds isolated from Garcinia subelliptica leaves were investigated. The hexane-soluble portion of MeOH extracts of G.
YoungSook Yun, Mariko Shioura, Yukio Hitotsuyanagi, Satoshi Yotsumoto, Yuji Takahashi, Yutaka Aoyagi, Takeshi Kinoshita, Koichi Takeya, Hideshi Inoue   +8 more
doaj   +1 more source

SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness

Journal of Lipid Research, 2006
Two splice variants are derived from the caspase-9 gene, proapoptotic caspase-9a and antiapoptotic caspase-9b, by either the inclusion or exclusion of an exon 3, 4, 5, and 6 cassette.
Autumn Massiello, Charles E. Chalfant
doaj   +1 more source