Results 61 to 70 of about 11,510,202 (303)

Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria. [PDF]

, 2015
To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline.
Cissé, O.H., Colborn, J.M., Koita, O.A., Krogstad, D.J., Ylöstalo, J.H.   +4 more
core   +1 more source

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

, 2015
Patients with HIV-associated tuberculosis (TB) initiating antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS). No biomarkers for TB-IRIS have been identified and the underlying mechanisms are unclear.
Anguiano, E, Banchereau, J, Bloom, C, Chaussabel, D, Deffur, A, Goliath, R, Graham, CM, Lai, RPJ, Maartens, G, Marais, S, Meintjes, G, Munagala, I, O'Garra, A, Schutz, C, Van der Plas, H, Wilkinson, KA, Wilkinson, RJ   +16 more
core   +2 more sources

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Cell Death and Differentiation, 2020
Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis.
I. Fernández-Duran, A. Quintanilla, Nuria Tarrats, J. Birch, P. Hari, F. Millar, A. Lagnado, Vanessa Smer-Barreto, M. Muir, V. Brunton, J. Passos, J. Acosta   +11 more
semanticscholar   +1 more source

The Expression of Caspase-3 and GRIM-19 in Non-mucinous Lung Adenocarcinoma and Their Clinicopathologic Significance

Düzce Tıp Fakültesi Dergisi, 2023
Aim: The current study aimed to investigate apoptotic proteins such as caspase-3 and GRIM-19 protein expression in non-mucinous lung adenocarcinomas and their clinicopathologic significance.
Handan Özdemir, Eda Yılmaz Akçay, Merih Tepeoğlu, Alev Ok Atılgan, Dalokay Kılıç, Leyla Hasanaliyeva   +5 more
doaj   +1 more source

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease [PDF]

, 2017
Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus.
Beyaert, Rudi, Francart, A, Kalai, M, Kip, Elodie, Lamoral, S, Nazé, F, Suin, V, Van Gucht, Steven, Vanden Berghe, Tom, Vandenabeele, Peter   +9 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer [PDF]

, 2016
The DNA mismatch repair (MMR) system corrects DNA replication mismatches thereby contributing to the maintenance of genomic stability. MMR deficiency has been observed in prostate cancer but its impact on the genomic landscape of these tumours is not ...
Böttcher, R. (René), Cano, D. (David), Dinjens, W.N.M. (Winand), Jenster, G.W. (Guido), Korput, H.A.G.M. (Hetty) van der, Teles Alves, I. (Inês), Trapman, J. (Hans)   +6 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source