Results 191 to 200 of about 334,347 (284)

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection. [PDF]

Nat Commun
M Bader S, Scherer L, Bhandari R, Motyer AJ, Cooney JP, Mackiewicz L, Dayton M, Sheerin D, V L Romero D, Schaefer J, Pang J, Chen S, Schoffer K, Wang L, Jin X, Batey D, Yip RKH, Zaman I, Rajasekhar P, Gartner MJ, Wilcox S, Whitehead L, Georgy SR, Maluenda A, Davidson KC, Allison CC, Bowden R, Brinkmann K, Asselin-Labat ML, Phipson B, Tanzer MC, Herold MJ, Samson AL, Vince JE, Strasser A, Pellegrini M, Doerflinger M.   +36 more
europepmc   +1 more source

Selectivity of new caspase 3 and 8 tetrapeptide substrates can be explained by automated docking analysis [PDF]

, 2009
Riad Schulz, Przemysław Reszka, PJ Bednarski   +2 more
openalex   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Caspase-8 and BID Caught in the Act with Cardiolipin: A New Platform to Provide Mitochondria with Microdomains of Apoptotic Signals. [PDF]

Cells
Petit PX.
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in childhood b cell acute lymphoblastic Leukemia. [PDF]

Discov Oncol
Arafah O, Ashraf M, Abd Elsalam AM, Elfishawi S, Hammad M.   +4 more
europepmc   +1 more source

Estrogen-induced dimerization and activation of ERα-fused caspase-8: Artificial reversal of the estrogenic hormone effect in carcinogenesis [PDF]

, 2011
Zhining Zhao, Qiang Zhou, Jiuxu Bai, Bo Yan, Weiwei Qin, Tao Wang, Yi Li, Angang Yang, Lintao Jia   +8 more
openalex   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis. [PDF]

Discov Oncol
Xie F, Song J, Tian Y, Zhang X, Chen T, Xu M.   +5 more
europepmc   +1 more source

Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis

, 2013
Tal Teitz, Madoka Inoue, Marcus B. Valentine, Kejin Zhu, Jerold E. Rehg, Wei Zhao, David Finkelstein, Yong‐Dong Wang, Melissa Johnson, Christopher Calabrese, Marcelo Rubinstein, Razqallah Hakem, William A. Weiss, Jill M. Lahti   +13 more
openalex   +1 more source