Results 211 to 220 of about 307,665 (262)

Polysome Profiling Proves Impaired IL-10 and Caspase-8 Translation in PBMCs of Hemodialysis Patients. [PDF]

Biomolecules
Dawood A, Fiedler R, Markau S, Girndt M, Ulrich C.   +4 more
europepmc   +1 more source

Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma. [PDF]

Proc Natl Acad Sci U S A
Bernabé-Rubio M, Watt FM.
europepmc   +1 more source

Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer. [PDF]

Cell Commun Signal
Gong W, Zhou D, Xu Q, Wang L, Luo M, Zhang Y, Liao Z, Xiong F, Zhao G, Zhao B, Gao Q, Fang Y.   +11 more
europepmc   +1 more source

TBK1 and Caspase-8 suppress necroptosis but activate NLRP3 inflammasome activation during CXCL4 and TLR8 costimulation. [PDF]

Cell Death Discov
Cui Y, Zhang Y, Yang C.
europepmc   +1 more source

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Caspase-8 for Outer Harmony

Science Signaling, 2009
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Sollberger, Gabriel, Beer, Hans-Dietmar
openaire   +4 more sources

From procaspase‐8 to caspase‐8: Revisiting structural functions of caspase‐8

Journal of Cellular Physiology, 2010
AbstractCaspase‐8 is well‐characterized to initiate an apoptotic pathway triggered by the external stimuli. The proximity‐driven model recently has been proposed to interpret the activation mechanism of caspase‐8 in so‐far unprecedent detail, in which dimerization, autocleavage, and inhibitor of caspase‐8 are indispensable. Intriguingly, death effector
Yang, Zhao, Xin, Sui, Hong, Ren
openaire   +2 more sources

Caspase-8: The double-edged sword

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and ...
Ranadip, Mandal, Joan Compte, Barrón, Izabela, Kostova, Sven, Becker, Klaus, Strebhardt   +4 more
openaire   +2 more sources

Non-apoptotic functions of caspase-8

Biochemical Pharmacology, 2008
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Jonathan, Maelfait, Rudi, Beyaert
openaire   +2 more sources

Caspase‐8 Gene Expression in Neuroblastoma

Annals of the New York Academy of Sciences, 2004
Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ida, Casciano, Barbara, Banelli, Michela, Croce, Alessandro, De Ambrosis, Angela, di Vinci, Ilaria, Gelvi, Gabriella, Pagnan, Chiara, Brignole, Giorgio, Allemanni, Silvano, Ferrini, Mirco, Ponzoni, Massimo, Romani   +11 more
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Anti-inflammatory Functions of Caspase-8

2010
Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
Akhil, Rajput, Tae-Bong, Kang, Konstantin, Bogdanov, Jin-Chul, Kim, Tehila, Ben-Moshe, Andrew, Kovalenko, David, Wallach   +6 more
openaire   +2 more sources