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Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation
Cold Spring Harbor Protocols, 2016The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria, Feoktistova +2 more
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Interferon-γ induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter
Journal of Pediatric Surgery, 2004The expression of caspase-8, a cysteine protease that is crucial for the apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent extracranial solid tumor of infants and children. Resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (TNF-alpha) receptor)--mediated apoptosis is thought to be ...
Sunghoon, Kim +3 more
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Caspase-8 in cancer biology and therapy
Cancer Letters, 2009Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human ...
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Nature Immunology, 2002
A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
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A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
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The Caspase-8 Modulator c-FLIP
Critical Reviews in Immunology, 2005Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
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Molecular cloning and characterization of mouse caspase‐8
European Journal of Biochemistry, 1998Fas (APO‐1/CD95) is a transmembrane receptor protein which induces apoptosis upon activation. In apoptosis triggered by Fas, a subset of cysteine proteases designated caspases is activated, playing a central role as effector molecules. Among these caspases, human caspase‐8 (FLICE/MACH/Mch5) has been isolated and shown to be indispensable for Fas ...
K, Sakamaki, S, Tsukumo, S, Yonehara
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Science Signaling, 2002
Investigation of two siblings with an autoimmune lymphoproliferative syndrome (ALPS) has resulted in the identification of novel functions for caspase-8. The caspases, a family of cysteine proteases, play a key role in executing apoptosis, a cell suicide process that counters cell proliferation to achieve a homeostatic balance.
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Investigation of two siblings with an autoimmune lymphoproliferative syndrome (ALPS) has resulted in the identification of novel functions for caspase-8. The caspases, a family of cysteine proteases, play a key role in executing apoptosis, a cell suicide process that counters cell proliferation to achieve a homeostatic balance.
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Caspase-8 is a player in pyroptosis
Science, 2018Immunology The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes. Inflammasome complexes can initiate both the maturation of inflammatory cytokines and pyroptotic cell death via the caspase-mediated cleavage of gasdermin D (GSDMD).
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Cell, 2020Rajendra Karki +2 more
exaly
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
Annual Review of Immunology, 2022Kate Schröder +2 more
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