Results 241 to 250 of about 5,538,011 (302)

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy

Angewandte Chemie, EarlyView.
We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu, Yura Lee, Sanghee Yoon, Yun Wang, Yejin Cho, Seongyu Choi, Lu Lu, Hua Zhang, Sun Choi, Ki Taek Nam, Juyoung Yoon   +10 more
wiley   +2 more sources

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice. [PDF]

Front Immunol
Pilot T, Solier S, Jalil A, Magnani C, Vanden Berghe T, Vandenabeele P, Masson D, Solary E, Thomas C.   +8 more
europepmc   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +2 more sources

TREM1 facilitates nonresponse to anti-TNF-α monoclonal antibodies in colitis via boosting ITCH/TAK1/caspase-8 axis-mediated macrophage pyroptosis. [PDF]

J Transl Med
Liu XM, Dai ZZ, Luo SJ, Zhai JY, Xie Y, Chen YW.   +5 more
europepmc   +1 more source

Caspase-8 in inflammatory diseases: a potential therapeutic target. [PDF]

Cell Mol Biol Lett
Zhang W, Zhu C, Liao Y, Zhou M, Xu W, Zou Z.   +5 more
europepmc   +1 more source

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases. [PDF]

ACS Bio Med Chem Au
Bourne CM, Raniszewski NR, Mahale AB, Kulkarni M, Exconde PM, Liu S, Yost W, Wrong TJ, Patio RC, Kardhashi M, Shosanya T, Kambayashi M, Discher BM, Brodsky IE, Burslem GM, Taabazuing CY.   +15 more
europepmc   +1 more source

Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission. [PDF]

J Am Heart Assoc
Shimada K, Yamaguchi I, Miyamoto T, Korai M, Koyama H, Enomoto N, Shimabuku A, Kitazato KT, Kanematsu Y, Takagi Y.   +9 more
europepmc   +1 more source

Evolutionary and Functional Analysis of Caspase-8 and ASC Interactions to Drive Lytic Cell Death, PANoptosis. [PDF]

Mol Biol Evol
Kumar SP, Nadendla EK, Malireddi RKS, Haque SA, Mall R, Neuwald AF, Kanneganti TD.   +6 more
europepmc   +1 more source

<i>Staphylococcus aureus</i> reprograms CASP8 (caspase 8) signaling to evade cell death and Xenophagy. [PDF]

Autophagy
Ying YT, Yang J, Ye HW, Chen MY, Liu X, Chen W, Xu JX, Tan X.   +7 more
europepmc   +1 more source