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Caspase-8: The double-edged sword
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and ...
Ranadip, Mandal +4 more
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Non-apoptotic functions of caspase-8
Biochemical Pharmacology, 2008Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Jonathan, Maelfait, Rudi, Beyaert
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Caspase‐8 Gene Expression in Neuroblastoma
Annals of the New York Academy of Sciences, 2004Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ida, Casciano +11 more
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Anti-inflammatory Functions of Caspase-8
2010Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
Akhil, Rajput +6 more
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Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation
Cold Spring Harbor Protocols, 2016The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria, Feoktistova +2 more
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Interferon-γ induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter
Journal of Pediatric Surgery, 2004The expression of caspase-8, a cysteine protease that is crucial for the apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent extracranial solid tumor of infants and children. Resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (TNF-alpha) receptor)--mediated apoptosis is thought to be ...
Sunghoon, Kim +3 more
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Caspase-8 in cancer biology and therapy
Cancer Letters, 2009Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human ...
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Nature Immunology, 2002
A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
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A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
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The Caspase-8 Modulator c-FLIP
Critical Reviews in Immunology, 2005Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
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Molecular cloning and characterization of mouse caspase‐8
European Journal of Biochemistry, 1998Fas (APO‐1/CD95) is a transmembrane receptor protein which induces apoptosis upon activation. In apoptosis triggered by Fas, a subset of cysteine proteases designated caspases is activated, playing a central role as effector molecules. Among these caspases, human caspase‐8 (FLICE/MACH/Mch5) has been isolated and shown to be indispensable for Fas ...
K, Sakamaki, S, Tsukumo, S, Yonehara
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