Results 41 to 50 of about 335,191 (205)

Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior

ACR Open Rheumatology, 2022
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype.
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein   +15 more
doaj   +1 more source

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b [PDF]

Journal of Biological Chemistry, 1997
Induction of apoptosis by the cell surface receptor CD95 (APO-1/Fas) has been shown to involve activation of a family of cysteine proteases (caspases). Recently, a new member of this family has been identified, designated FLICE (caspase-8/MACH/Mch5). FLICE is part of the CD95 death-inducing signaling complex and is therefore the most upstream caspase ...
Scaffidi, C., Medema, J. P., Krammer, P. H., Peter, M. E.   +3 more
openaire   +2 more sources

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]

, 2020
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L.   +11 more
core   +1 more source

Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice [PDF]

, 2013
Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic functions and is essential ...
Bohgaki, Miyuki, Bohgaki, Toshiyuki, Hakem, Anne, Hakem, Razqallah, Matysiak-Zablocki, Elzbieta, Mozo, Julien, Salmena, Leonardo, Sanchez, Otto, Strasser, Andreas   +8 more
core   +1 more source

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

Neurobiology of Disease, 2021
Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness; however, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation.
Xiangjun Yang, Qun Zeng, Gülgün Tezel
doaj   +1 more source

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions [PDF]

, 2014
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis.
Aguileta, Miguel, Bertrand, Mathieu, De Keyser, Julie, Dubuisson, Christel, Estornes, Yann, Goossens, Vera, Kersse, Kristof, Samali, A, Vandenabeele, Peter   +8 more
core   +2 more sources

Caspase 8: igniting the death machine [PDF]

Structure, 1999
Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.
openaire   +2 more sources

Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]

, 2015
Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S., Gumral, N., Karahan, N., Ozguner, M.F., Saygin, M., Çalişkan, Sadettin   +5 more
core   +1 more source

Role of caspase-8 in thymus function [PDF]

Cell Death & Differentiation, 2013
The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition. During the developmental process, 98% of thymocytes die by apoptosis. Thus apoptosis is a dominant process in the thymus and occurs through either death by neglect or negative selection or through ...
POZZESI, NICOLA, Fierabracci A, LIBERATI, Anna Marina, MARTELLI, Maria Paola, AYROLDI, Emira Maria, RICCARDI, Carlo, DELFINO, Domenico Vittorio   +6 more
openaire   +3 more sources

Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis

Galician Medical Journal, 2016
The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT).
M. I. Sheremet, V. O. Shidlovskyy, L. P. Sydorchuk, R. I. Sydorchuk   +3 more
doaj   +1 more source