Results 51 to 60 of about 335,290 (304)

Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis

Galician Medical Journal, 2016
The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT).
M. I. Sheremet, V. O. Shidlovskyy, L. P. Sydorchuk, R. I. Sydorchuk   +3 more
doaj   +1 more source

Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2022
Background Immune activation, neuroinflammation, and cell death are the hallmarks of multiple sclerosis (MS), which is an autoimmune demyelinating disease of the central nervous system (CNS). It is well-documented that the cellular inhibitor of apoptosis
Debolina D. Biswas, Rebecca K. Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela S. Gupta, Michael J. Surace, Anuj Tharakan, Jessie W. Yester, Reetika Bhardwaj, Daniel H. Conrad, Tomasz Kordula   +10 more
doaj   +1 more source

cMet and fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells [PDF]

, 2005
Fas receptor is constitutively expressed on endothelial cells; however, these cells are highly resistant to Fas-mediated apoptosis. In this study, we examined death-inducing signaling complex (DISC) formation in endothelial cells after Fas receptor ...
Brady, H.J.M., Smyth, L.A.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells [PDF]

, 2017
BACKGROUND: Caffeic acid has been shown to induce apoptosis in MG63 osteosarcoma cells. Along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3.
Hudono, K. F. (Karina), Putri, A. A. (Amelia), Putri, C. A. (Chantika), Sandra, F. (Ferry)   +3 more
core   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Expressão gênica de caspases 3 e 8 em timo e baço de ratas recém-desmamadas e imunossuprimidas por glicocorticóide Genic expression of caspases 3 and 8 in thymus and spleen of glicocorticoid-immunossupressed weaned rats

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005
Determinou-se a expressão gênica das caspases 3 e 8 mediante transcrição reversa de mRNA total e reação em cadeia da polimerase (RT-PCR) para avaliar a apoptose em timo e baço de ratas imunossuprimidas por glicocorticóides.
J.J. Batista, A.S. Martins, L. Moro, A.C. Vasconcelos   +3 more
doaj   +1 more source

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source

Apaf-1- and Caspase-8-independent apoptosis [PDF]

Cell Death & Differentiation, 2012
Two major apoptosis pathways, the mitochondrial and death receptor pathways, are well recognized. Here we established cell lines from the fetal thymus of Apaf-1-, Caspase-9-, or Bax/Bak-deficient mice. These cell lines were resistant to apoptosis induced by DNA-damaging agents, RNA or protein synthesis inhibitors, or stress in the endoplasmic reticulum.
Imao, T, Nagata, S
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source