Results 61 to 70 of about 335,290 (304)

dsDNA ASCs for caspase 8-mediated apoptosis [PDF]

Cell Death & Differentiation, 2013
In the dim and distant past of research, there was only place for one form of cell death. Necrosis was the only known way for cells to die, and pathologists generally defined all cells with a dying phenotype as necrotic. This restricted view was challenged in 1972 when Kerr et al.1 defined apoptosis as a novel form of cell death, which was ...
Grabinger, T., Peterburs, P., Brunner, Thomas   +2 more
openaire   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Effect of Diclofenac on Caspase-8 and Caspase-9 Activity in Cervical Cancer Cells (HeLa) in Cell Culture

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Studies have shown that drugs can affect on proliferation of cancer cells. The main aim of this study was to determine the effects of diclofenac on caspase-8 and caspase-9 activity in cervical cancer cells (HeLa) in cell ...
Minoo Erfani, Masoud Ghorbani, Rahim Ahmadi   +2 more
doaj  

Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo

Neurobiology of Disease, 2003
We have investigated the role of caspase-8 and its mode of activation during apoptosis of adult rat retinal ganglion cells (RGCs) in vivo. Retinal pro-caspase-8 expression was almost completely restricted to RGCs.
J.H Weishaupt, R Diem, P Kermer, S Krajewski, J.C Reed, M Bähr   +5 more
doaj   +1 more source

A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer

Cancer Biology & Medicine, 2022
Objective: Although our previous genome-wide association study (GWAS) has identified chromosome 2q33.1 as a susceptibility locus for non-small cell lung cancer (NSCLC), the causal variants remain unclear.
Xu Zhang, Na Qin, Jingyi Fan, Chang Zhang, Qi Sun, Yayun Gu, Meng Zhu, Erbao Zhang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Zhibin Hu, Hongbing Shen   +12 more
doaj   +1 more source

Caspase-8: Clipping off RIG-I Signaling [PDF]

Immunity, 2011
Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.
Roth, Susanne, Ruland, Jürgen
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ginger extract (Zingiber officinale Roscoe) triggers apoptosis in hepatocarcinogenesis induced rats [PDF]

, 2008
Ginger extract has been reported previously by our group to exhibit anticancer and an-tioxidant effects by reducing tumour burden and lipid peroxidation respectively in he-patocarcinogenesis induced rats.
Harlianshah H,, Looi ML,, Noor Aini AH,, Shafina Hanim MH,, Shahriza ZA,, Suzana M,, Wan Zurinah WN,, Yasmin Anum MY,   +7 more
core  

The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. [PDF]

, 2017
The linear ubiquitin chain assembly complex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of linear ubiquitin linkages de novo LUBAC is a crucial component of various immune receptor signalling pathways.
De Miguel, D, Draber, P, Hartwig, T, Kantari-Mimoun, C, Kupka, S, Lafont, E, Reichert, M, Shimizu, Y, Spit, M, Sprick, MR, Taraborrelli, L, Walczak, H   +11 more
core   +1 more source

Peptide drug cortexin inhibits brain caspase-8 [PDF]

Biomeditsinskaya Khimiya, 2017
Cortexin, a drug containing hydrolyzed brain peptides, has long been used in clinics, but the mechanisms of its action remain obscure. We have hypothesized that cortexin-related neuroprotection is associated with the ability of the drug to inhibit brain proteases. Cortexin effectively inhibited brain caspase-8, while its effects on caspase-1, -3, -9,
A A, Yakovlev, A A, Lyzhin, L G, Khaspekov, A B, Guekht, N V, Gulyaeva   +4 more
openaire   +2 more sources