Results 71 to 80 of about 335,290 (304)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Caspase 8 inhibits programmed necrosis by processing CYLD [PDF]

Nature Cell Biology, 2011
Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1). However, the dominant function of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs 2-6) during embryogenesis and haematopoiesis(
O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT.   +7 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Cytotoxic Effects of Testosterone on Gastric Cancer Cell Line (AGS) and Evaluation of Caspase-3, -8, and -9 Activity

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Various studies have shown that sex steroids affect cancer cells at cellular and molecular level. In this study, the anti-proliferation effects of testosterone, was investigated on gastric cancer cell line (AGS) and activity ...
Neda Amani, Mehrdad Shariati, Rahim Ahmadi, Saeed Khatamsaz, Mokhtar Mokhtari   +4 more
doaj  

Acanthopagrus schlegelii FADD and caspase-8 are involved in the regulation of apoptosis and inflammation

Animal Advances
Acanthopagrus schlegelii is a farmed fish with significant economic value in China. Fas-associated protein with death domain (FADD) and caspase-8 are related to apoptosis and inflammation; however, the specific functions of FADD and caspase-8 in A ...
Jianlong Yang, Weishang Kong, Chuangchuang Wei, Xiaoqing Wang, Qian Meng, Chaofeng Jia, Zhiwei Zhang, Jiajia Li, Qingguo Meng   +8 more
doaj   +1 more source

Pharmacological Inhibition of Caspase-8 Suppresses Inflammation-Induced Angiogenesis in the Cornea

Biomolecules, 2020
Inflammation-induced angiogenesis is closely related to many diseases and has been regarded as a therapeutic target. Caspase-8 has attracted increasing attention for its immune properties and therapeutic potential in inflammatory disorders.
Yunzhe Tian, He Li, Xiuxing Liu, Lihui Xie, Zhaohao Huang, Weihua Li, Zhuang Li, Yuan Pan, Xiaoqing Chen, Wenru Su   +9 more
doaj   +1 more source

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria [PDF]

The Open Virology Journal, 2008
Human Immunodeficiency Virus (HIV) protease initiates apoptosis of HIV-infected cells by proteolytic cleavage of procaspase 8, creating a novel peptide termed casp8p41. Expression of casp8p41 alone is sufficient to initiate caspase-dependent cell death associated with mitochondrial depolarization.
Algeciras-Schimnich, Alicia, Belzacq-Casagrande, Anne-Sophie, Bren, Gary D, Nie, Zilin, Taylor, Julie A, Rizza, Stacey A, Brenner, Catherine, Badley, Andrew D   +7 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Tissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma [PDF]

, 2006
Background The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis ...
Li-yan Xue, Nan Hu, Yong-mei Song, Shuang-mei Zou, Jian-zhong Shou, Lu-xia Qian, Li-qun Ren, Dong-mei Lin, Tong Tong, Zu-gen He, Qi-min Zhan, Philip R Taylor, Ning Lu, J McCann, SY Law, K Nabeya, H Su, J Zhou, T Kan, A Luo, J Zhou, YC Hu, YC Hu, J Kononen, XP Hao, Y Moriya, MI Koukourakis, T Tong, Y Shimada, Y Han, S Nagata, S Kase, K Galaktionov, K Nishioka, A Grothey, SL Swierczynski, A Maitra, Y Hashimoto, PG Chu, H Takahashi, L Su, A Gasparoni, M Morifuji, MP Grace, A Franchi, Z Suo, LC Alldridge, SH Ahn, T Masaki, CP Paweletz, JM Garcia Pedrero, RE Burgeson, C Pyke, N Koshikawa, B Skyldberg, S Aoki, P Kohlberger, C Lenander, PL Porter, B Le Bail   +59 more
core   +2 more sources

The Caspase-8 Dimerization/Dissociation Balance Is a Highly Potent Regulator of Caspase-8, -3, -6 Signaling* [PDF]

Journal of Biological Chemistry, 2010
Apoptosis is driven by positive feedback activation between aspartate-specific cysteinyl proteases (caspases). These feedback loops ensure the swift and efficient elimination of cells upon initiation of apoptosis execution. At the same time, the signaling network must be insensitive to erroneous, mild caspase activation to avoid unwanted, excessive ...
Maximilian L, Würstle, Maike A, Laussmann, Markus, Rehm   +2 more
openaire   +2 more sources