Results 171 to 180 of about 262,302 (283)

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Genome-wide association studies identify the role of caspase-9 in kidney disease. [PDF]

Sci Adv, 2021
Doke T, Huang S, Qiu C, Sheng X, Seasock M, Liu H, Ma Z, Palmer M, Susztak K.   +8 more
europepmc   +1 more source

Cyclic-AMP Inhibits Nitric Oxide-Induced Apoptosis in Human Osteoblast: The Regulation of Caspase-3, -6, -9 and the Release of Cytochrome c in Nitric Oxide-Induced Apoptosis by cAMP.

, 2001
Han‐Jung Chae, Soo‐Wan Chae, Nyeon‐Hyoung An, Jong-Hwan Kim, Chulwon Kim, Sim-Keun Yoo, Hong‐Hee Kim, Zang-Hee Lee, Hyung‐Ryong Kim   +8 more
openalex   +2 more sources

Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway [PDF]

, 2002
Farzaneh Pirnia, E Schneider, Daniel Betticher, Markus Borner   +3 more
openalex   +1 more source

Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux

Advanced Science, EarlyView.
PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan   +14 more
wiley   +1 more source

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. [PDF]

ACS Chem Biol, 2021
Araya LE, Soni IV, Hardy JA, Julien O.
europepmc   +1 more source

Pre-processed caspase-9 contained in mitochondria participates in apoptosis [PDF]

, 2002
Paola Costantini, J-M Bruey, Maria Castedo, David Métivier, Markus Loeffler, Santos A. Susín, L Ravagnan, Naoufal Zamzami, Carmen Garrido, Guido Kroemer   +9 more
openalex   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling. [PDF]

Nat Commun
Matsui K, Watanabe M, Yamamoto S, Kawagoe S, Ikeda T, Ohashi H, Kuroda T, Koda N, Morimoto K, Kinoshita Y, Inage Y, Saito Y, Fukunaga S, Fujimoto T, Tajiri S, Matsumoto K, Kobayashi E, Yokoo T, Yamanaka S.   +18 more
europepmc   +1 more source

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells. [PDF]

Front Pharmacol, 2022
Li T, Shi L, Liu W, Hu X, Hui Y, Di M, Xue S, Zheng Y, Yao M, Li C, Meng K.   +10 more
europepmc   +1 more source