Results 171 to 180 of about 4,575,594 (299)

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.

, 2017
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
M Ploesser (7788878), MA Hughes (7670561), C Sticht (7788872), T Tenev (7788875), S Horn (7788866), MR Sprick (7788881), M MacFarlane (7674281), M Leverkus (7788884), R Schilling (7788869), P Meier (7737890)   +9 more
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Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion. [PDF]

Front Neurosci, 2023
Avrutsky MI, Chen CW, Lawson JM, Snipas SJ, Salvesen GS, Troy CM.   +5 more
europepmc   +1 more source

Investigating Survivin-Caspase-9 Interactions for Rational Design of Caspase-9 Specific Peptide Inhibitor

© 2025 Saharnaz RafieeCaspase-9 is a key initiator of the intrinsic apoptosis pathway, where its activation through the apoptosome triggers a cascade leading to cell death.
Rafiee, Saharnaz
core  

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury. [PDF]

Curr Neuropharmacol, 2023
Unnisa A, Greig NH, Kamal MA.
europepmc   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Molecular Docking and Simulation-Binding Analysis of Plant Phytochemicals with the Hepatocellular Carcinoma Targets Epidermal Growth Factor Receptor and Caspase-9. [PDF]

Molecules, 2023
Mustafa G, Younas S, Mahrosh HS, Albeshr MF, Bhat EA.   +4 more
europepmc   +1 more source

A Complex between Atg7 and Caspase-9 [PDF]

Journal of Biological Chemistry, 2014
Jie Han, Wen Hou, Leslie A. Goldstein, Donna B. Stolz, Simon C. Watkins, Hannah Rabinowich   +5 more
openaire   +1 more source

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

, 2011
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu, Rupesh Chaturvedi, Yan Shi, Hamwei Cao, Fang Yan, Lihong Wang, Liping Liu, Keith Wilson, D. Brent Polk   +8 more
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