Results 261 to 270 of about 4,575,594 (299)
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Caspase 9 is decreased in psoriatic epidermis
Acta Histochemica, 2006Psoriasis is a proliferative and inflammatory disease of the skin. Caspase 9 is responsible for initiating the caspase activation cascade during apoptosis. Apoptosis is a physiological mechanism of homeostasis and development, and caspases are the executioners of apoptosis.
Oemeroglu, SUNA +5 more
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The International Journal of Biochemistry & Cell Biology, 2000
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
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Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
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Caspase-9 as a therapeutic target for treating cancer
Expert Opinion on Therapeutic Targets, 2014Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee, Kim +2 more
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The effect of caspase-9 in the differentiation of SH-SY5Y cells
European Journal of Pharmacology, 2021Neuroblastoma is the most common solid malignant tumor in infants and young children. Its origin is the incompletely committed precursor cells from the autonomic nervous system. Neuroblastoma cells are multipotent cells with a high potency of differentiation into the neural cell types.
Zahra Madadi +4 more
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Expression of phosphorylated caspase‐9 in gastric carcinomas
APMIS, 2007Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Nam Jin, Yoo +3 more
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cDNA cloning and promoter analysis of rat caspase-9
Biochemical Journal, 2001Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on the gene promoter.
J, Nishiyama +3 more
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Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele
Fertility and Sterility, 2011To assess sperm caspase-9 activity in infertile oligoasthenoteratozoospermic (OAT) men with and without varicocele.Prospective.Academic setting.Eighty men: healthy fertile control subjects (n = 20), OAT (n = 25), and OAT associated with left-side varicocele (n = 35).History taking, clinical examination, semen analysis,assessment of seminal caspase-9 ...
Adel, Zalata +5 more
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Caspase 9: context-dependent killer
Trends in Cell Biology, 1998Abstract KUIDA, K. et al . (1998) Reduced apoptosis and cytochrome c -mediated caspase activation in mice lacking caspase 9 Cell 94, 325–337 Hakem, R. et al .
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Regulation of Cell Death Protease Caspase-9 by Phosphorylation
Science, 1998Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 (pro-Casp9) in cells. Cytochrome c–induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from cells expressing either active Ras or Akt.
M H, Cardone +7 more
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Activation of caspase 9 in a rat model of experimental glaucoma
Current Eye Research, 2002We investigated retinal ganglion cell (RGC) death and activation of caspase 9 in rats with experimental glaucoma.Elevated intraocular pressure (IOP) was induced in rats using the Morrison model. Surviving backlabeled RGC were counted and TUNEL staining detected apoptosis.
Virve A, Hänninen +4 more
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