Results 271 to 280 of about 262,302 (283)
Some of the next articles are maybe not open access.
The International Journal of Biochemistry & Cell Biology, 2000
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
openaire +2 more sources
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
openaire +2 more sources
Expression of phosphorylated caspase‐9 in gastric carcinomas
APMIS, 2007Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Sug Hyung Lee +3 more
openaire +3 more sources
Caspase-9 as a therapeutic target for treating cancer
Expert Opinion on Therapeutic Targets, 2014Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee Kim +2 more
openaire +3 more sources
Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele [PDF]
Fertility and Sterility, 2011 To assess sperm caspase-9 activity in infertile oligoasthenoteratozoospermic (OAT) men with and without varicocele.Prospective.Academic setting.Eighty men: healthy fertile control subjects (n = 20), OAT (n = 25), and OAT associated with left-side varicocele (n = 35).History taking, clinical examination, semen analysis,assessment of seminal caspase-9 ...
Mohamed Ahmed Elbaz +5 more
openaire +2 more sources
The effect of caspase-9 in the differentiation of SH-SY5Y cells
European Journal of Pharmacology, 2021Neuroblastoma is the most common solid malignant tumor in infants and young children. Its origin is the incompletely committed precursor cells from the autonomic nervous system. Neuroblastoma cells are multipotent cells with a high potency of differentiation into the neural cell types.
Zahra Madadi +4 more
openaire +2 more sources
Caspase 9: context-dependent killer
Trends in Cell Biology, 1998Abstract KUIDA, K. et al . (1998) Reduced apoptosis and cytochrome c -mediated caspase activation in mice lacking caspase 9 Cell 94, 325–337 Hakem, R. et al .
openaire +2 more sources
Activation of caspase 9 in a rat model of experimental glaucoma
Current Eye Research, 2002We investigated retinal ganglion cell (RGC) death and activation of caspase 9 in rats with experimental glaucoma.Elevated intraocular pressure (IOP) was induced in rats using the Morrison model. Surviving backlabeled RGC were counted and TUNEL staining detected apoptosis.
Ellen E. Freeman +4 more
openaire +3 more sources
Analysis of Apaf-1 and Caspase 9 in Tumorigenesis [PDF]
, 2002 Abstract : The replicative exhaustion of Human diploid fibroblasts (HDFs) in culture is associated with an "irreversible" cell-cycle arrest known as replicative senescence. However, young cells can enter a similar phenotype to replicative senescence in response to expression of certain mitogenic oncogenes, oxidative stress, and DNA damage.
openaire +1 more source
Cytochrome C and Caspase-9 Expression in Huntington 's Disease
NeuroMolecular Medicine, 2002There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner caspases.
Steven M. Hersch +12 more
openaire +3 more sources
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
Science, 1998Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 (pro-Casp9) in cells. Cytochrome c–induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from cells expressing either active Ras or Akt.
Henning R. Stennicke +7 more
openaire +2 more sources