Results 251 to 260 of about 514,126 (359)

Targeting panoptosis: a narrative review of its therapeutic potential in kidney disease. [PDF]

BMC Nephrol
Guo Y, Zhao Y, Qiao Y, Xing Y, Fang Y, Zhao Y, Yang H, Chen Y, Yang B.   +8 more
europepmc   +1 more source

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

Journal of Clinical Investigation, 2017
K. Cheng, Shiqin Xiong, Zhiming Ye, Z. Hong, Anke Di, K. Tsang, Xiao‐pei Gao, S. An, M. Mittal, S. Vogel, Edward A. Miao, J. Rehman, A. Malik   +12 more
semanticscholar   +1 more source

One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids

Advanced Science, EarlyView.
This study presents a one‐step system that delivers different drug doses to brain organoids and monitors their neural activity using integrated 3D microelectrodes. By combining dose‐specific microfluidic delivery with high‐resolution electrophysiological recording, the platform enables simultaneous, real‐time screening of neural responses across ...
Hyogeun Shin, Yeonjoo An, Ju‐Hyun Lee, Ji Hun Kim, Renuka Prasad, Keun‐Tae Kim, Hoon‐Chul Kang, Woong Sun, Seung‐Woo Cho, Il‐Joo Cho   +9 more
wiley   +1 more source

Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway. [PDF]

Neuromolecular Med
Li S, Gao Y, Zhang Y, Zhang J, Zhao Y, Chang C, Gao X, Zhang J, Yang G.   +8 more
europepmc   +1 more source

Proteolytic cleavage of β‐catenin by caspases: an in vitro analysis

, 1999
Marc Van de Craen, Geert Berx, Ilse Van den Brande, Walter Fiers, Wim Declercq, Peter Vandenabeele   +5 more
openalex   +2 more sources

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity. [PDF]

J Med Biochem
Veljkovic A, Hadzi-Djokic J, Kocic G, Li X, Roumeliotis S, Sokolović D, Klisic A.   +6 more
europepmc   +1 more source

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Programmed cell death in triple-negative breast cancer. [PDF]

Cell Mol Biol Lett
Liu Y, He J, Chen J, Chen T, Li W, Yang Z, Zeng F.   +6 more
europepmc   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source