Results 251 to 260 of about 509,167 (309)

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Expansion of the Structure-Activity Relationship Profile of Triaminopyrimidines as Inhibitors of Caspase-1. [PDF]

Chem Biol Drug Des
East A, Polasek CG, Miller EA, Ranganathan S, Reda ID, Patel A, Ahlers CD, Zingales SK, Karver CE.   +8 more
europepmc   +1 more source

Caspase-1 Activation via Rho GTPases: A Common Theme in Mucosal Infections?

, 2010
Andreas J. Müller, Claudia Hoffmann, Wolf‐Dietrich Hardt   +2 more
openalex   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells. [PDF]

Sci Rep
Zhang N, Yan L, Cao H, Zhang N, Zhang T, Guan S, Liu Q.   +6 more
europepmc   +1 more source

Activation of caspase-9 within the Apaf-1 apoptosome

, 2015
Chu-Chiao Wu
openalex   +2 more sources

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Corrigendum to "miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury". [PDF]

J Immunol Res
europepmc   +1 more source

Maresin 1 Ameliorates Blue Light Overexposure-Induced Meibomian Gland Dysfunction via Inhibition of NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis. [PDF]

Invest Ophthalmol Vis Sci
Wu M, He HL, Wang C, Wang B, Li YZ, Zhou SR, Cai WY, Xiong N, Zhang MC, Xie HT.   +9 more
europepmc   +1 more source