Results 251 to 260 of about 24,063,457 (338)

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation. [PDF]

Ren Fail
Guo T, Xie T, Chen X, Zhong J, Bai Z, Liang H, Zhao X, Fang M, Xiao Y, Zhang J.   +9 more
europepmc   +1 more source

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

, 2000
Yunyi Wei, Ted Fox, Steve P. Chambers, JoAnne Sintchak, Joyce T. Coll, Julian M.C. Golec, Lora Swenson, Keith P. Wilson, Paul S. Charifson   +8 more
openalex   +1 more source

Defective Cytochrome c-dependent Caspase Activation in Ovarian Cancer Cell Lines due to Diminished or Absent Apoptotic Protease Activating Factor-1 Activity [PDF]

, 2001
Beni B. Wolf, Martin Schüler, Wěi Li, Beth Eggers-Sedlet, Wilson Lee, Pankaj Tailor, Patrick Fitzgerald, Gordon B. Mills, Douglas R. Green   +8 more
openalex   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Mitochondrial Dysfunction Increases Expression of Endothelin-1 and Induces Apoptosis Through Caspase-3 Activation in Rat Cardiomyocytes In Vitro

, 2000
Koichi Yuki, Takashi Miyauchi, Yoshihiko Kakinuma, Nobuyuki Murakoshi, Takahiko Suzuki, Jun‐Ichi Hayashi, Katsutoshi Goto, Iwao Yamaguchi   +7 more
openalex   +2 more sources

Hydrogen sulfide mitigates ox‑LDL‑induced NLRP3/caspase‑1/GSDMD dependent macrophage pyroptosis by S‑sulfhydrating caspase‑1. [PDF]

Mol Med Rep
Jia Z, Zhang X, Li Z, Yan H, Tian X, Luo C, Ma K, Li L, Zhang L.   +8 more
europepmc   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Caspase-Dependent Apoptosis of Cells Expressing the Chemokine Receptor CXCR4 Is Induced by Cell Membrane-Associated Human Immunodeficiency Virus Type 1 Envelope Glycoprotein (gp120)

, 2000
Martine Biard-Piechaczyk, Véronique Robert-Hebmann, Véronique Richard, Joachim Roland, Robert A. Hipskind, Christian Devaux   +5 more
openalex   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source