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Corrigendum to "miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury". [PDF]

J Immunol Res
europepmc   +1 more source

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Caspase-1 activation by Salmonella

Trends in Cell Biology, 2003
Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Järveläinen, H., Galmiche, A., Zychlinsky, A.   +2 more
openaire   +3 more sources

Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

Microbiology and Immunology, 2019
AbstractInflammasomes are innate immune mechanisms that activate caspase‐1 in response to a variety of stimuli, including Salmonella infection. Active caspase‐1 has a potential to induce two different types of cell death, depending on the expression of the pyroptosis mediator gasdermin D (GSDMD); following caspase‐1 activation, GSDMD‐sufficient and ...
Mamunur Rashid Mahib, Shoko Hosojima, Hiroko Kushiyama, Takeshi Kinoshita, Toshihiko Shiroishi, Takashi Suda, Kohsuke Tsuchiya   +6 more
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Assessing Caspase-1 Activation

2016
The caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1β) and IL-18. In this chapter, we describe the technique of Western blot to assess caspase-1 activation. This method provides multiple information within one experiment.
Guey, B., Petrilli, V.
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Role of Caspase‐1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase‐1‐deficient mice

Annals of Neurology, 2002
AbstractCaspase 1 plays a pivotal role in generating mature cytokine interleukin‐1β. Interleukin‐1β is implicated as a mediator of pneumococcal meningitis, both in experimental models and in humans. We demonstrated here that (1) Caspase 1 mRNA and protein expression is upregulated in the brain during experimental pneumococcal meningitis, and (2 ...
Uwe, Koedel, Frank, Winkler, Barbara, Angele, Adriano, Fontana, Richard A, Flavell, Hans-Walter, Pfister   +5 more
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Immunoblotting for Active Caspase-1

2013
Immunoblotting for caspase-1 is the gold-standard method of detecting inflammasome activation. In contrast to IL-1β-based readouts, it can be used in an experimental setup independent of de novo gene expression. Here, we present protocols for the preparation and precipitation of supernatant samples containing activated caspase-1 as well as protocols ...
Christopher, Jakobs, Eva, Bartok, Andrej, Kubarenko, Franz, Bauernfeind, Veit, Hornung   +4 more
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Spodoptera littoralis caspase-1, a Lepidopteran effector caspase inducible by apoptotic signaling

Apoptosis, 2005
The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) can successfully infect Spodoptera frugiperda SF9 cells, but in contrast, in Spodoptera littoralis SL2 cells it induces apoptosis aborting the infection. To understand better the mechanism of induction and execution of apoptosis in SL2 cells, we identified and characterized ...
Q, Liu, Y, Qi, N, Chejanovsky
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Hypoxic induction of caspase-11/caspase-1/interleukin-1β in brain microglia

Molecular Brain Research, 2003
Caspase-11 is an inducible protease that plays an important role in both inflammation and apoptosis. Inflammatory stimuli induce and activate caspase-11, which is required for the activation of caspase-1 or interleukin-1beta (IL-1beta) converting enzyme (ICE).
Nam-Gon, Kim, Heasuk, Lee, Eunyung, Son, Oh-Young, Kwon, Jae-Yong, Park, Jae-Hoon, Park, Gyeong Jae, Cho, Wan Sung, Choi, Kyoungho, Suk   +8 more
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Plaguing Caspase-1 Through Rac

Science's STKE, 2004
The Yersinia bacteria, whose most notorious member ( Y. pestis ) is the organism that causes bubonic plague, inject Yop proteins into target cells. The individual Yop effectors, which cooperate to prevent phagocytosis and suppress the inflammatory response, have highly specific effects.
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Obesity development in caspase-1-deficient mice

International Journal of Obesity, 2013
Caspase-1 is a member of the intracellular cysteine protease family that mediates inflammation through the activation of the cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). As mice lacking IL-18 become obese and insulin resistant, and both IL-18 and IL-1β have a role in overall energy balance, we sought to determine whether caspase-1 ...
H, Wang, W, Capell, J H, Yoon, S, Faubel, R H, Eckel   +4 more
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