Results 281 to 290 of about 504,320 (308)
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Nucleotide Sequence of Equine Caspase-1 cDNA
DNA Sequence, 1999Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides.
S, Wardlow +4 more
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Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Nature Immunology, 2008Caspase-1 serves an essential function in the initiation of inflammation by proteolytically maturing the cytokines interleukin 1 beta and interleukin 18. Several Nod-like receptors activate caspase-1 in response to microbial and 'danger' signals by assembling cytosolic protein complexes called 'inflammasomes'.
Meissner, F., Molawi, K., Zychlinsky, A.
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Quantifying Caspase-1 Activity in Murine Macrophages
2018The caspase-1 protease is a core component of multiprotein inflammasome complexes, which play a critical role in regulating the secretion of mature, bioactive pro-inflammatory cytokines interleukin (IL)-1β and IL-18. The activity of caspase-1 is often measured indirectly, by monitoring cleavage of cellular caspase-1 substrates, processing of caspase-1 ...
Boucher, Dave +3 more
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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
Nature, 2023Yanjie Hou, Yong Cao, Meng-Qiu Dong
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Cell, 2020Min Zheng, Rajendra Karki, Peter Vogel
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Molecular mechanisms of caspase regulation during apoptosis
Nature Reviews Molecular Cell Biology, 2004Yigong Shi
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It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Nature Reviews Molecular Cell Biology, 2011Andrew Oberst
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