Results 51 to 60 of about 24,258,002 (357)

Caspase-1: is IL-1 just the tip of the ICEberg? [PDF]

Cell Death & Disease, 2012
Caspase-1, formerly known as interleukin (IL)-1-converting enzyme is best established as the protease responsible for the processing of the key pro-inflammatory cytokine IL-1β from an inactive precursor to an active, secreted molecule. Thus, caspase-1 is regarded as a key mediator of inflammatory processes, and has become synonymous with inflammation ...
Denes, A., Lopez-Castejon, G., Brough, D.   +2 more
openaire   +3 more sources

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Cell Death and Disease, 2019
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system.
Lingbin Sun, Wei-Qing Ma, Wenli Gao, Yanmei Xing, Lixin Chen, Z. Xia, Zhongjun Zhang, Zhongliang Dai   +7 more
semanticscholar   +1 more source

Caspase-1ζ, a new splice variant of the caspase-1 gene

Genomics, 2004
Five alternatively spliced mRNA isoforms of human caspase-1 have been identified previously and we report here the cloning of a new isoform, named CASP1 zeta (zeta), from human ovarian surface epithelial cell cDNA. The new isoform zeta is identical to the alpha isoform but missing 79 nucleotides in the coding region of the prodomain of procaspase-1 ...
Peter C.K. Leung, Nelly Auersperg, Peixiang Li, Qiang Feng   +3 more
openaire   +3 more sources

Caspase-1 inflammasomes in infection and inflammation [PDF]

Journal of Leukocyte Biology, 2007
AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed, Kanneganti, Thirumala‐devi, Franchi, Luigi, Núñez, Gabriel   +3 more
openaire   +4 more sources

Caspase-1 as a regulatory molecule of lipid metabolism [PDF]

Lipids in Health and Disease, 2020
AbstractCaspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18).
Tesfahun Dessale Admasu, Zeleke Geto, Birhanu Ayelign, Gashaw Dessie, Meseret Derbew Molla   +4 more
openaire   +3 more sources

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

Cell Reports, 2020
Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui   +6 more
doaj   +1 more source

Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment [PDF]

Journal of Investigative Dermatology, 2015
The inflammasome is a complex of proteins that has a critical role in mounting an inflammatory response in reply to a harmful stimulus that compromises the homeostatic state of the tissue. The NLRP3 inflammasome, which is found in a wound-like environment, is comprised of three components: the NLRP3, the adaptor protein ASC and caspase-1. Interestingly,
Lee, Dai-Jen, Du, Fei, Chen, Shih-Wei, Nakasaki, Manando, Rana, Isha, Shih, Vincent FS, Hoffmann, Alexander, Jamora, Colin   +7 more
openaire   +4 more sources

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Nature Communications, 2018
Alzheimer's disease (AD) is an intractable progressive neurodegenerative disease characterized by cognitive decline and dementia. An inflammatory neurodegenerative pathway, involving Caspase-1 activation, is associated with human age-dependent cognitive ...
Joseph Flores, Anastasia Noël, B. Foveau, Jeffrey Lynham, Clotilde Lecrux, A. LeBlanc   +5 more
semanticscholar   +1 more source

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Cells, 2022
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard   +3 more
doaj   +1 more source