Results 131 to 140 of about 331,832 (268)

Acidic pH Greatly Enhances Calbindin-D28K's Inhibitory Effect on Caspase-3: Implications for Alzheimer's Therapeutics. [PDF]

Cell Biochem Funct
Kinkead J, Thompson RJ, Milton ME, Cavanagh J.   +3 more
europepmc   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

The effects of zinc oxide nanoparticles on the oxidative stress, caspase-3, cytokine and immunity in rats. [PDF]

Vet Med (Praha)
Gultekin M, Eren M, Koca FD, Bozbek CK, Develi N.   +4 more
europepmc   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Caspase 3/8/9 Apoptotic Pathway Deregulation Analysis in Laryngeal Squamous Cell Carcinoma. [PDF]

Maedica (Bucur)
Athanasopoulos M, Tsiambas E, Papanastasiou G, Papouliakos S, Vylliotis A, Tsouvelas G, Mastronikolis N, Kyrodimos E, Kavantzas N, Agrogiannis G.   +9 more
europepmc   +1 more source

Dietary isothiocyanate sulforaphene induces reactive oxygen species, caspase -9, -8, -3-dependent apoptosis and modulates PTEN/PI3Kinase in human cervical cancer cells

, 2018
Yun‐Hee Rhee, Arindam Mondal, Phil‐Sang Chung, Jin-Chul Ahn   +3 more
openalex   +2 more sources

Overexpression of Bcl‐X_L prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA [PDF]

, 1998
David J. Granville, Huijun Jiang, Mary T An, Julia G. Levy, Bruce M. McManus, David W. C. Hunt   +5 more
openalex   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Caspase-3 deficiency inhibits the development and anti-tumor response of bone marrow-derived dendritic cells. [PDF]

Discov Oncol
Liu J, Du K, Chen Y, Zheng G, Zhang H, Zhang W, Hu X, Feng F.   +7 more
europepmc   +1 more source

Effect of 2LMISEN<sup>®</sup> on Long-Term Hippocampal Neurons Culture as a Screening Senescent Cells Model: p16<sup>INK4A</sup> and Caspase 3 Quantification

, 2019
Nicoletta Libera Lilli, Delphine Révy, Christelle Volteau, Sandra Robelet, Béatrice Lejeune   +4 more
openalex   +2 more sources