Results 231 to 237 of about 474,288 (237)

Prognostic Significance of the Immunohistochemical Staining of Cleaved Caspase-3, an Activated Form of Caspase-3, in Gliomas

Clinical Cancer Research, 2007
Abstract Purpose: Gliomas are common tumors of the central nervous system, and the majority of patients with gliomas have a poor prognosis. The prediction of prognosis is very important in selecting treatment. In the present study, we retrospectively examined the immunohistochemical staining of cleaved caspase-3 (CC3), an activated form ...
Tetsuo Nomiyama, Tatsuya Kobayashi, Kazuhiro Hongo, Junya Masumoto, Tsuyoshi Tada, Jun Nakayama   +5 more
openaire   +3 more sources

Caspase 3 and 8 deficiency in human neuroblastoma

Cancer Genetics and Cytogenetics, 2003
An altered apoptotic response represents a pivotal feature of cancer and is involved in cancerogenesis and resistance to chemotherapy. So far, however, only a few studies have been devoted to survey caspase content in malignant cell lines and primary tumor specimens. In this report, we investigated the expression of two pivotal caspases, 3 and 8, in 63
IOLASCON A, BORRIELLO, Adriana, GIORDANI L, CUCCIOLLA V, MORETTI A, MONNO F, CRINITI V, MARZULLO A, CRISCUOLO M, DELLA RAGIONE, Fulvio   +9 more
openaire   +5 more sources

Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Mar Royuela, Gonzalo Rodríguez-Berriguete, Gabriel Olmedilla, F R Bethencourt, Benito Fraile, Ricardo Paniagua, Pilar Martínez-Onsurbe, Laura Galvis   +7 more
openaire   +3 more sources

Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes

Zygote, 2004
The current consensus in the literature is that ovulated oocytes that are not fertilized die by apoptosis, but the details of the proteins involved in the apoptotic pathways have not been elucidated. In this paper we confirm that caspase-3, the executioner of apoptosis, is expressed in mouse oocytes, and show that two initiators of apoptosis, caspase-8
Donald M. O'Malley, Carol M. Warner, Adrian Papandile, David A. Tyas   +3 more
openaire   +2 more sources

Survivin does not inhibit caspase-3 activity

Blood, 2000
Conway et al recently reported that alternatively spliced forms of mouse survivin exhibit different antiapoptotic properties.[1][1] This was inferred from inhibition of recombinant caspase-3 catalytic activity using a standard chromogenic assay in the presence of increasing concentrations ...
Dario C. Altieri, Damon Banks, Janet Plescia, Haichao Zhang, Shi-Chung Ng, Jun Chen, Saul H. Rosenberg   +6 more
openaire   +3 more sources

Quantification of Active Caspase-3 and Active Caspase-8 in Microglia Cells

2013
During microglia activation the levels of active caspase-3, caspase-7 and caspase-8 are increased, which leads to the transcription of proinflammatory cytokines and factors. As such, the induction of caspase activity in microglia can be used as a marker for activation.
openaire   +3 more sources

Caspase-3 and Caspase-7

2013
Tom Vanden Berghe, Kristof Kersse, Peter Vandenabeele   +2 more
openaire   +1 more source