Results 251 to 260 of about 548,432 (354)

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Caspase-3 deficiency inhibits the development and anti-tumor response of bone marrow-derived dendritic cells. [PDF]

Discov Oncol
Liu J, Du K, Chen Y, Zheng G, Zhang H, Zhang W, Hu X, Feng F.   +7 more
europepmc   +1 more source

Author response: CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

, 2015
Xun Ding, Gongping Sun, Yewubdar G Argaw, Jessica Wong, Sreesankar Easwaran, Denise J. Montell   +5 more
openalex   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Platelet-rich plasma improves caspase-3 of skin graft treated with Tilapia Mozambique bio-dressing. [PDF]

Open Vet J
Etriwati E, Abellisa A, Ferasyi TR, Sugito S, Amiruddin A, Zamzami RS, Erwin E.   +6 more
europepmc   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Correction: Non-genetic inactivation of caspase-3 and P53 increases cancer cell fitness by PDIA4 redistribution. [PDF]

Oncogene
Twito G, Abu Abayed FA, Gilad A, Biadsy S, Gavriel N, Sheikh Suliman S, Mizrahi Y, Megged H, Tenenboim M, Abu-Freha N, Igbaria A.   +10 more
europepmc   +1 more source

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways. [PDF]

, 1998
Vercammen, Dominique, Brouckaert, Greet, Denecker, Geertrui, Van De Craen, Marc, Declercq, Wim, Fiers, Walter, Vandenabeele, Peter   +6 more
core   +2 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Novel Imidazopyridine-Oxadiazole β‑Tubulin Inhibitors Suppress Breast Cancer Migration and Induce Caspase-3-Mediated Apoptosis. [PDF]

ACS Omega
Cakir M, Kuzu B.
europepmc   +1 more source