Results 231 to 240 of about 336,919 (263)

Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

Apoptosis, 2007
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death.
Takai, Y., Matikainen, T., Jurisicova, A., Kim, M., Trbovich, A., Fujita, E., Nakagawa, T., Lemmers, Bénédicte, Flavell, R., Hakem, R., Momoi, T., Yuan, J., Tilly, J., Perez, G.   +13 more
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Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7

Annals of Anatomy - Anatomischer Anzeiger, 2016
Vasculogenic mimicry (VM) describes the process by which aggressive cancer cells form extracellular matrix-rich, vessel-like mesh works, which supply nutrients and oxygen. Furthermore, it offers a new route for tumor cell invasion and metastasis and thus a correspondingly poor prognosis and survival rate for affected patients.
Manuel, Linder, Thomas, Tschernig
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Kinetic comparison of procaspase-3 and caspase-3

Archives of Biochemistry and Biophysics, 2005
Caspases, the key enzymes in apoptosis, are synthesized as proenzymes and converted into active form by proteolytic cleavage. The residues on active site reorganize during the activation process as shown in the comparative studies of crystallographic structures of procaspase-7 and its mature form.
Pratap, Karki, Jungsup, Lee, Song Yub, Shin, Byungyun, Cho, Il-Seon, Park   +4 more
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Posttranslational Regulation of Bim by Caspase‐3

Annals of the New York Academy of Sciences, 2007
Abstract:  Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably ...
Hidetoshi, Wakeyama, Toru, Akiyama, Yuho, Kadono, Masaki, Nakamura, Yasushi, Oshima, Kozo, Nakamura, Sakae, Tanaka   +6 more
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Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
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Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes

Zygote, 2004
The current consensus in the literature is that ovulated oocytes that are not fertilized die by apoptosis, but the details of the proteins involved in the apoptotic pathways have not been elucidated. In this paper we confirm that caspase-3, the executioner of apoptosis, is expressed in mouse oocytes, and show that two initiators of apoptosis, caspase-8
Adrian, Papandile, David, Tyas, Donald M, O'Malley, Carol M, Warner   +3 more
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Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete, Laura, Galvis, Benito, Fraile, Fermín R, de Bethencourt, Pilar, Martínez-Onsurbe, Gabriel, Olmedilla, Ricardo, Paniagua, Mar, Royuela   +7 more
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A Crucial Role of Caspase 3 and Caspase 8 in Paclitaxel-Induced Apoptosis

Molecular Cell Biology Research Communications, 1999
The anticancer drug paclitaxel is well known as an inhibitor of microtubule depolymerization, resulting in mitosis arrest. We investigated the mechanism underlying antitumor effects of paclitaxel on the lung adenocarcinoma cell line LC-2-AD. Less than 10 microg/ml paclitaxel induced mitosis arrest upon LC-2-AD, followed by apoptosis, but more than 30 ...
H, Oyaizu, Y, Adachi, S, Taketani, R, Tokunaga, S, Fukuhara, S, Ikehara   +5 more
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The effect of uremia and hemodialysis on caspase-1 and caspase-3 activity in neutrophils

Journal of Nephrology, 2010
Abstract Background: Neutrophils in uremia maintain chronic inflammation, which contributes to malnutrition and immunity disorders. The influence of hemodialysis on the life span of neutrophils is unclear, although many authors postulate its apoptotic effect. Erythropoietin (EPO) is an antiapoptotic factor for various cells.
Irmina, Korzeniewska-Dyl, Krzysztof, Wróblewski, Ewa, Majewska, Dariusz, Moczulski   +3 more
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Quantification of Active Caspase-3 and Active Caspase-8 in Microglia Cells

2013
During microglia activation the levels of active caspase-3, caspase-7 and caspase-8 are increased, which leads to the transcription of proinflammatory cytokines and factors. As such, the induction of caspase activity in microglia can be used as a marker for activation.
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