Results 251 to 260 of about 17,150,662 (399)

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells

International Journal of Cancer, 2018
Min Zhou, Xinjian Liu, Zonghai Li, Qian Huang, Fang Li, Chuan-Yuan Li   +5 more
semanticscholar   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality [PDF]

, 2000
Dennis Lee, Scott A. Long, Jerry L. Adams, George Chan, Kalindi Vaidya, Terry Francis, Kristine Kikly, James D. Winkler, Chiu-Mei Sung, Christine Debouck, Susan B. Richardson, Mark A. Levy, Walter E. DeWolf, Paul M. Keller, Thaddeus A. Tomaszek, Martha S. Head, Margret Ryan, R. Curtis Haltiwanger, Po‐Huang Liang, Cheryl A. Janson, Patrick McDevitt, Kyung Johanson, N.O. Concha, Winnie Chan, Sherin S. Abdel‐Meguid, Alison M. Badger, Michael W. Lark, Daniel P. Nadeau, Larry J. Suva, Maxine Gowen, Mark Nuttall   +30 more
openalex   +1 more source

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Cell, 1997
Hua Zou, W. Henzel, X. Liu, Alexis Lutschg, Xiaodong Wang   +4 more
semanticscholar   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Evaluation of Apoptotic Caspase-3 Immunopositivity in Human Model of Asphyxial Death. [PDF]

Int J Mol Sci
Del Duca F, Treglia M, La Russa R, De Simone S, Cipolloni L, Maiese A, Frati P.   +6 more
europepmc   +1 more source

Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury [PDF]

, 2000
Joe E. Springer, Robert D. Azbill, Stephanie A. Nottingham, Sarah E. Kennedy   +3 more
openalex   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

Caspase 3-dependent killing of host cells by the parasite Entamoeba histolytica [PDF]

, 2000
Christopher D. Huston, Eric R. Houpt, Barbara J. Mann, Chang S. Hahn, William A. Petri   +4 more
openalex   +1 more source