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Investigation of the Effect of Borago officinalis on Bax/Bcl-2/Caspase-3 Pathways Against Spleen Toxicity Induced by Lead Acetate in Rats

open access: diamond
Samet Tekin   +7 more
openalex   +2 more sources

Activation of human endogenous retroviruses by Sox proteins induces cell apoptosis via the caspase-3 pathway. [PDF]

open access: yesFront Microbiol
Hossain MJ   +11 more
europepmc   +1 more source

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy. [PDF]

open access: yesNat Commun
Ma J   +20 more
europepmc   +1 more source
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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

Nature Medicine, 2000
Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
T S, Zheng   +7 more
openaire   +2 more sources

Caspase-3 Activators as Anticancer Agents

Current Protein & Peptide Science, 2023
Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
openaire   +2 more sources

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