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Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer. [PDF]
Yan Y +6 more
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Activation of human endogenous retroviruses by Sox proteins induces cell apoptosis via the caspase-3 pathway. [PDF]
Hossain MJ +11 more
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Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy. [PDF]
Ma J +20 more
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Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis. [PDF]
Wang Q, Shen P, Wu W, Zhu J, Xu J.
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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
Nature Medicine, 2000Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
T S, Zheng +7 more
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Caspase-3 Activators as Anticancer Agents
Current Protein & Peptide Science, 2023Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
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