Results 321 to 330 of about 548,432 (354)

Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
openaire   +2 more sources

Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7

Annals of Anatomy - Anatomischer Anzeiger, 2016
Vasculogenic mimicry (VM) describes the process by which aggressive cancer cells form extracellular matrix-rich, vessel-like mesh works, which supply nutrients and oxygen. Furthermore, it offers a new route for tumor cell invasion and metastasis and thus a correspondingly poor prognosis and survival rate for affected patients.
Manuel, Linder, Thomas, Tschernig
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MK2 Phosphorylates Caspase‐3, Facilitates Nuclear Translocation of Caspase 3, and Regulates Apoptosis

The FASEB Journal, 2022
Background Apoptosis is a necessary and key pathologic feature in the development of acute lung injury (ALI). Previous research has identified MAPK Activated Protein Kinase 2 (MK2) as a potential regulator in the development of apoptosis, by facilitating the nuclear translocation of active caspase‐3, the ...
Othello Lance Del Rosario, Karthik Suresh, Larissa Shimoda, Madhavi Rane, Mahendra Damarla   +4 more
openaire   +1 more source

Kinetic comparison of procaspase-3 and caspase-3

Archives of Biochemistry and Biophysics, 2005
Caspases, the key enzymes in apoptosis, are synthesized as proenzymes and converted into active form by proteolytic cleavage. The residues on active site reorganize during the activation process as shown in the comparative studies of crystallographic structures of procaspase-7 and its mature form.
Pratap, Karki, Jungsup, Lee, Song Yub, Shin, Byungyun, Cho, Il-Seon, Park   +4 more
openaire   +2 more sources

Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway

Biochemical and Biophysical Research Communications, 2002
C(2)-ceramide, a cell-permeable analog of ceramide, caused cell death in cultured rat cortical neuronal cells. C(2)-ceramide-induced neuronal loss was accompanied by upregulation of caspase-3 activity, measured by cleavage of its fluorogenic substrate Ac-DEVD-AMC.
Vilen A, Movsesyan, Alexander G, Yakovlev, Elvira A, Dabaghyan, Bogdan A, Stoica, Alan I, Faden   +4 more
openaire   +2 more sources

Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

Apoptosis, 2007
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death.
Takai, Y., Matikainen, T., Jurisicova, A., Kim, M., Trbovich, A., Fujita, E., Nakagawa, T., Lemmers, Bénédicte, Flavell, R., Hakem, R., Momoi, T., Yuan, J., Tilly, J., Perez, G.   +13 more
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Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete, Laura, Galvis, Benito, Fraile, Fermín R, de Bethencourt, Pilar, Martínez-Onsurbe, Gabriel, Olmedilla, Ricardo, Paniagua, Mar, Royuela   +7 more
openaire   +2 more sources

Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes

Zygote, 2004
The current consensus in the literature is that ovulated oocytes that are not fertilized die by apoptosis, but the details of the proteins involved in the apoptotic pathways have not been elucidated. In this paper we confirm that caspase-3, the executioner of apoptosis, is expressed in mouse oocytes, and show that two initiators of apoptosis, caspase-8
Adrian, Papandile, David, Tyas, Donald M, O'Malley, Carol M, Warner   +3 more
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Caspase-3, Caspase-8, and Nuclear Factor-??B Expression in Human Cholesteatoma

Otology & Neurotology, 2006
Cholesteatoma is characterized by the accumulation of keratinizing epithelium resulting from the proliferation and differentiation of epithelium. Researchers are presently unraveling the role that apoptosis plays in the disease seen in cholesteatoma epithelium. Caspases play a key role in apoptosis.
Masumichi, Miyao, Hideo, Shinoda, Sugata, Takahashi   +2 more
openaire   +2 more sources

Caspase-3 and Caspase-7

2013
Tom Vanden Berghe, Kristof Kersse, Peter Vandenabeele   +2 more
openaire   +1 more source