Results 351 to 360 of about 17,150,662 (399)

Development of caspase-3-selective activity-based probes for PET imaging of apoptosis. [PDF]

EJNMMI Radiopharm Chem
Lauwerys L, Beroske L, Solania A, Vangestel C, Miranda A, Van Giel N, Adhikari K, Lambeir AM, Wyffels L, Wolan D, Van der Veken P, Elvas F.   +11 more
europepmc   +1 more source

Graphene Oxide‐Based Gene Modulation in Preferential Elimination of Lung Cancer Cells in a 3D Tumor Microenvironment Model

Advanced NanoBiomed Research, EarlyView.
Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli, Sadman Sakib, Fabio Variola, Shan Zou   +3 more
wiley   +1 more source

<i>Brucella suis</i> S2 strain inhibits IRE1/caspase-12/caspase-3 pathway-mediated apoptosis of microglia HMC3 by affecting the ubiquitination of CALR. [PDF]

mSphere
Wang Z, Wang Y, Yang S, Wang Z, Yang Q.
europepmc   +1 more source

Immunoengineering eines Photocage‐geschützten 5′‐Triphosphat‐Oligoribonukleotid‐Liganden zur spatiotemporalen Kontrolle der RIG‐I‐Aktivierung bei Tumoren

Angewandte Chemie, EarlyView.
In dieser Studie wird eine Methode zur präzisen Kontrolle von Retinsäure‐Induzierbaren‐Gens‐I (RIG‐I) vorgestellt, einem Rezeptor des angeborenen Immunsystems, der, wenn er aktiviert wird, antitumorale Immunreaktionen und Zelltod von Krebszellen auslöst.
Sandra Anika Lewash, Vivien Rose McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta I. Toma, Eva Bartok, Martin Schlee, Thomas Zillinger, Alexander Heckel, Gunther Hartmann   +11 more
wiley   +1 more source

MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells. [PDF]

Sci Rep
Chen J, Ji Z, Wu D, Wei S, Zhu W, Peng G, Hu M, Zhao Y, Wu H.   +8 more
europepmc   +1 more source

Immunoengineering of a Photocaged 5´‐triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG‐I Activation in Cancer

Angewandte Chemie International Edition, EarlyView.
This study presents a method for precise control of RIG‐I (retinoic acid inducible gene I), an innate immune receptor of RNA that, when activated, induces anti‐tumor immune responses and cancer cell death. By incorporating photocage modifications into RNA ligands, we enable a spatially and temporally regulated immune response and offer a targeted ...
Sandra Anika Lewash, Vivien Rose McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta I. Toma, Eva Bartok, Martin Schlee, Thomas Zillinger, Alexander Heckel, Gunther Hartmann   +11 more
wiley   +1 more source

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells. [PDF]

PLoS Biol
Samarasekera G, Go NE, Choutka C, Xu J, Takemon Y, Chan J, Chan M, Perera S, Aparicio S, Morin GB, Marra MA, Chittaranjan S, Gorski SM.   +12 more
europepmc   +1 more source

HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. [PDF]

EMBO Rep
Yang J, Li Y, Li H, Zhang H, Guo H, Zheng X, Yu XF, Wei W.   +7 more
europepmc   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

Animal Research and One Health, EarlyView.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan   +12 more
wiley   +1 more source

Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway. [PDF]

Open Med (Wars)
Long X, Yang Y, Zhou K.
europepmc   +1 more source