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Caspase‐3: Structure, function, and biotechnological aspects
Biotechnology and applied biochemistry, 2021Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until
M. Asadi +6 more
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Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy
Chemical Biology and Drug Design, 2021Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner caspase, plays an imperative role in apoptosis and becomes a primary target for ...
P. Yadav +3 more
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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
Nature Medicine, 2000Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
Timothy S. Zheng +7 more
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Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells
Apoptosis, 2007Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death.
Takai, Y. +13 more
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Kinetic comparison of procaspase-3 and caspase-3
Archives of Biochemistry and Biophysics, 2005Caspases, the key enzymes in apoptosis, are synthesized as proenzymes and converted into active form by proteolytic cleavage. The residues on active site reorganize during the activation process as shown in the comparative studies of crystallographic structures of procaspase-7 and its mature form.
Pratap Karki +4 more
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Caspase-3 Activators as Anticancer Agents
Current Protein & Peptide Science, 2023Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
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Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7
Annals of Anatomy - Anatomischer Anzeiger, 2016Vasculogenic mimicry (VM) describes the process by which aggressive cancer cells form extracellular matrix-rich, vessel-like mesh works, which supply nutrients and oxygen. Furthermore, it offers a new route for tumor cell invasion and metastasis and thus a correspondingly poor prognosis and survival rate for affected patients.
Manuel Linder, Thomas Tschernig
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Posttranslational Regulation of Bim by Caspase‐3
Annals of the New York Academy of Sciences, 2007Abstract: Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably ...
Masaki Nakamura +6 more
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