Results 71 to 80 of about 530,883 (357)

Cleaved Caspase-3 Sebagai Uji Apoptosis Pada Kanker Serviks IIB Tipe Sel Skuamosa Yang Mendapat Kemoterapi Neoadjuvan Cisplatin [PDF]

, 2015
Tujuan: mencari peningkatan ekspresi cleaved caspase-3 pada pasien kanker serviks IIB tipe sel skuamosa sesudah pemberian kemoterapi neoadjuvan cisplatin dan mencari kapan waktu yang tepat untuk mendeteksi apoptosis menggunakan cleaved caspase-3.
Askandar, B. (Brahmana), Mustokoweni, S. (Sjahjenny), Putra, A. K. (Andra)   +2 more
core   +2 more sources

Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients

Clinical Psychopharmacology and Neuroscience, 2023
Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples.RNA was isolated from the peripheral blood of 39 schizophrenia patients' and healthy ...
Ebubekir Dirican, Halil Özcan, Sevgi Karabulut Uzunçakmak, Uğur Takım   +3 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]

, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S., Aplin, Andrew E., Erkes, Dan A., Fernandes-Alnemri, Teresa, Nardone, Alexandria, Rogers, Corey   +5 more
core   +3 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Association of B-cell Lymphoma Protein-2 and Caspase-3 Expression in Ovarian Cancer [PDF]

, 2013
Ovarian cancer remains a major problem of women's health in the world, including Indonesia, and is associated with high rates of incidence and mortality. There are many efforts in early diagnosis on ovarian cancer, but until now there have not been found
Budiana, I. N. (I)
core  

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease [PDF]

, 2017
Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus.
Beyaert, Rudi, Francart, A, Kalai, M, Kip, Elodie, Lamoral, S, Nazé, F, Suin, V, Van Gucht, Steven, Vanden Berghe, Tom, Vandenabeele, Peter   +9 more
core   +2 more sources

Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction

Frontiers in Pharmacology, 2018
Cytotoxic chemotherapy, still the most widely adopted anticancer treatment, aims at eliminating cancer cells inducing apoptosis with DNA damaging agents, exploiting the differential replication rate of cancer vs.
Emanuele Bruni, Albrecht Reichle, Manuel Scimeca, Elena Bonanno, Elena Bonanno, Lina Ghibelli   +5 more
doaj   +1 more source

Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation [PDF]

Mutagenesis, 2005
Aneugenic and clastogenic agents are good inducers of both micronuclei and apoptosis. In its turn, apoptosis may modify the threshold values for the induction of micronuclei. This is of major concern for accurate assessment of hazard related to exposure to mutagens.
Decordier, Ilse, Cundari, Enrico, Volders, Micheline   +2 more
openaire   +6 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source