Results 71 to 80 of about 331,832 (268)

Apoptose na maturação placentária de vacas em diferentes estágios de gestação: evidenciação imuno-histoquímica e bioquímica

Pesquisa Veterinária Brasileira, 2011
Apoptose tem um papel importante na manutenção da homeostase placentária, e o desequilíbrio desse processo pode comprometer a gestação. O objetivo do presente estudo foi avaliar a ocorrencia de apoptose em amostras de placenta de vacas em diferentes ...
Karina K.O.L. Meça, Helen L Del Puerto, Luciana V. Rodrigues, Milene A. Rachid, Nubia B. Pereira, Márcia G.L. Cândido, Anilton C. Vasconcelos   +6 more
doaj   +1 more source

Endothelial Apoptosis in Pulmonary Hypertension Is Controlled by a microRNA/Programmed Cell Death 4/Caspase-3 Axis [PDF]

, 2014
Kevin P. White, Yvonne Dempsie, Paola Caruso, Emma Wallace, Robert A. McDonald, Hannah Stevens, Mark E. Hatley, Eva van Rooij, Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker   +10 more
openalex   +1 more source

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Advanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri‐Zadeh, Jeff W. M. Bulte   +7 more
wiley   +1 more source

Molecular Docking Study of Annona muricata Bioactive Compounds Against Caspase 3

Archives of Advances in Biosciences
Introduction: Soursop, or Annona muricata, is a plant that has long been used to treat a variety of illnesses, including cancer. The purpose of this study was to use an in-silico method to assess the anti-cancer activity of chemicals produced from ...
Raimot Ojedokun, Qawiyy Ogunrinola, Adebayo Olugbode   +2 more
doaj   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

Frontiers in Pharmacology
BackgroundTrihydroxysterols and their analogues accumulate in several pathologies, including neurodegenerative diseases, cancers, and atherosclerosis.
Jiaxi Chen, Yuan He, Min Zhao, Zihan Liu, Zixin Su, Chuanzhou Li, Chuanzhou Li, Chen Yang, Chen Yang, Jieping Zhang, Shuichun Mao, Hua Han, Zhenyu Cai, Wen Zhang, Wen Zhang   +14 more
doaj   +1 more source

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Neurobiology of Disease, 2002
Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn, Robert A. Rissman, Michael C. Davis, Young Eun Kim, Carl W. Cotman, Elizabeth Head   +5 more
doaj   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Expression of Beclin-1 and Caspase-3 After the Myocardial Contusion in Rats With High and Low Stress Resistance

Фундаментальная и клиническая медицина
Aim. To evaluate the activity of autophagy and apoptosis in the myocardium of rats with differentstress resistance after the modeling of myocardial contusion.Materials and Methods. The study was performed on 106 white male rats weighing 250-300 g.
E. I. Klyuchnikova, O. V. Korpacheva, S. I. Mozgovoi, A. N. Zolotov, A. V. Kononov   +4 more
doaj   +1 more source

In Vitro Evaluation of Cytotoxic Effects of Nickel Oxide Nanoparticles on Human Neuroblastoma Cell Line (SH-SY5Y)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: Despite the many applications of nickel oxide nanoparticles (Nio NPs) in industry and biomedicine, limited studies have been performed in the case of the cytotoxicity of these nanoparticles onnervous system yet.
Mozhdeh Hajimohammadjafar tehrania, Mahsa Ale-Ebrahim, Mojtaba Falahati, Shahram Zarabiyan   +3 more
doaj