Results 91 to 100 of about 390,973 (308)

Role of apoptotic and anti-apoptotic mechanisms in erythroblast differentiation [PDF]

, 2004
The present study focuses on deciphering the differentiation mechanisms of erythroid cells. In particular, the involvement of apoptotic mechanisms in erythroblast differentiation and enucleation was examined.
Hristoskova, Sashka
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Pyroptosis was suppressed in ZIKV-infected macrophages with pro-caspase-1 knockdown.

, 2022
(A) Knockdown of pro-caspase-1 in THP-1 cells. Cell lysates were prepared from lentiviral vector-transduced THP-1 cell lines, expressing shRNA1, 2, or 3 targeting mRNA of pro-caspase-1, for western blot analyses with pro-caspase-1 antibody to examine the
Yufeng Yu (10308089), Xian Qi (197348), Carol J. Cardona (8321163), Zheng Xing (335154), Chunxia Wen (10308086), Chengfeng Gao (5371597)   +5 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers

Controlling the access of proteases to cleavable peptides placed at specific locations within macromolecular architectures represents a powerful strategy for biologically responsive materials design.
Bin Liu (5899), Hadiqa Zafar (4335619), Hung V.-T. Nguyen (2885066), Jeremiah A. Johnson (1316577)   +3 more
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Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
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TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3 [PDF]

, 2013
Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here,
Sergio Candel, Mercader Huber, Nadia, Cayuela, María L, Mulero, Victoriano, María P. Sepulcre, Sepulcre, María P, Raquel Espín, Candel, Sergio, Gonzalez-Rosa, Juan Manuel, González-Rosa, Juan M, Alcaraz-Pérez, Francisca, Meseguer, José, Roca, Francisco J, Francisca Alcaraz-Pérez, María L. Cayuela, Mercader, Nadia, Nadia Mercader, Espín, Raquel, Juan M. González-Rosa, Victoriano Mulero, Francisco J. Roca, José Meseguer   +21 more
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ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture.

, 2016
We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways.
Xuezhong Liu, Jiaqiao Zhu, Mengfei Long, Hui Zou, Yan Yuan (20767), Yan Yuan, Tongwang Luo (3353570), Jiaqiao Zhu (753911), Gang Liu (81776), Jianhong Gu (753909), Gang Liu, Yi Wang (32470), Zongping Liu, Ruilong Song (827410), Yi Wang, Xuezhong Liu (753908), Zongping Liu (827411), Jianchun Bian (753910), Jianhong Gu, Ruilong Song, Mengfei Long (3353567), Tongwang Luo, Jianchun Bian, Hui Zou (666389)   +23 more
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Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

THE ROLE OF INFLAMMASOME AND CASPASE-1 IN REGULATING ADAPTIVE RESPONSE TO OXIDATIVE STRESS IN MOUSE HEPATOCYTES [PDF]

, 2013
In myeloid cells, oxidative stress can induce the activation of caspase-1 through canonical inflammasome signaling, which leads to the release of proinflammatory cytokines IL-1β/IL-18 and a potentially damaging inflammatory response.
Sun, Qian
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