Results 101 to 110 of about 390,973 (308)
Caspase-3, 3-Nitrotyrosine (3-NT) staining scores and nitrite measurements at 14 day post-infection.
, 2018 (A) Semi-quantification of immunohistochemical Caspase-3 staining in distal colon from C. rodentium infected mice with and without VIP treatment (B) Semi-quantification of immunohistochemical 3-NT in distal colon from infected mice with and without VIP ...
Nazanin Navabi (324297) +3 more
core +1 more source
Caspase-3 participates in the E10.5 lethality of RIPK1 D325A mutant mice.
, 2021 (A) IF staining of E10.5 YS of indicated genotypes with anti-PECAM (red) and anti-Cl.CASP3 (green) antibodies. Scale bars, 50 μm. Images are representative of 4 embryos per genotype.
Ye-hsuan Sun (11338002) +12 more
core +1 more source
Caspase-9 swings both ways in the apoptosome
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj +1 more source
Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
Neurobiology of Disease, 2002 Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn +5 more
doaj +1 more source
Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats
Advanced Functional Materials, EarlyView.We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang +18 more
wiley +1 more source
Caspase-3 mediates in part hippocampal apoptosis in sepsis [PDF]
, 2013 The brain is one of the first organs affected during sepsis development resulting in apoptosis for a short-term and cognitive impairment for a long-term.
Grandgirard, Denis +5 more
core +1 more source
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
, 2019 Caspase-3 and HRG levels in secretomes from all transferred embryos resulting and not resulting in a pregnancy.
Raghad Samir (8156802) +5 more
core +1 more source
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
eLifeCaspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME).
Hang Xu +4 more
doaj +1 more source