Results 91 to 100 of about 456,031 (305)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Peptide drug cortexin inhibits brain caspase-8 [PDF]

Biomeditsinskaya Khimiya, 2017
Cortexin, a drug containing hydrolyzed brain peptides, has long been used in clinics, but the mechanisms of its action remain obscure. We have hypothesized that cortexin-related neuroprotection is associated with the ability of the drug to inhibit brain proteases. Cortexin effectively inhibited brain caspase-8, while its effects on caspase-1, -3, -9,
A A, Yakovlev, A A, Lyzhin, L G, Khaspekov, A B, Guekht, N V, Gulyaeva   +4 more
openaire   +2 more sources

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism [PDF]

, 2015
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microglia in ...
Burguillos García, Miguel Ángel, Herrera Carmona, Antonio José, Joseph, Bertrand, Martínez de Pablos, Rocío, Venero Recio, José Luis, Viceconte, Nikenza   +5 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Acanthopagrus schlegelii FADD and caspase-8 are involved in the regulation of apoptosis and inflammation

Animal Advances
Acanthopagrus schlegelii is a farmed fish with significant economic value in China. Fas-associated protein with death domain (FADD) and caspase-8 are related to apoptosis and inflammation; however, the specific functions of FADD and caspase-8 in A ...
Jianlong Yang, Weishang Kong, Chuangchuang Wei, Xiaoqing Wang, Qian Meng, Chaofeng Jia, Zhiwei Zhang, Jiajia Li, Qingguo Meng   +8 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

PB1755: CASPASE 8, CASPASE 10 AND FAS GENE POLYMORPHISMS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

HemaSphere, 2022
M. Lourou, E. Kampouraki, M. Zervou, I. Pelagiadis, N. Katzilakis, G. Goulielmos, E. Stiakaki   +6 more
doaj   +1 more source

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

EMBO Molecular Medicine, 2019
Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee   +9 more
doaj   +1 more source

Cyprinid Herpesvirus 2 miR-C12 Attenuates Virus-Mediated Apoptosis and Promotes Virus Propagation by Targeting Caspase 8

Frontiers in Microbiology, 2019
DNA viruses, most notably members of the herpesvirus family, generally encode miRNAs to mediate both virus and host genes expression. We previously demonstrated that Cyprinid herpesvirus 2 (CyHV-2) encodes 17 miRNAs that are involved in innate immune ...
Jianfei Lu, Jianfei Lu, Jianfei Lu, Zhaoyuan Shen, Zhaoyuan Shen, Zhaoyuan Shen, Liqun Lu, Liqun Lu, Liqun Lu, Dan Xu, Dan Xu, Dan Xu, Dan Xu   +12 more
doaj   +1 more source