Results 71 to 80 of about 7,657,629 (247)

Assessment of apoptotic mediators in different periodontal plights: apoptosis markers in periodontal diseases

Dental Journal
Background: Highly expressed apoptosis markers in an inflammatory condition were observed following periodontal breakdown with obscure lineaments. Purpose: This trial aimed to assess the gingival crevicular fluid (GCF) level of caspase-3, -8, -9, and ...
Asem Mohammed Kamel Ali, Bahaa M. Badr, Abdullah I. Ali, Mohamoud A. Mizer, Ahmed M. Abdelrahman, Asmaa Rashad Ali, Abdel-Moneim M. I. Ghorab, Mohammed G. M. El Sherbeny, Azza A. Althoqapy   +8 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Identification and validation of a pyroptosis-related gene signature in intracranial aneurysm

Open Life Sciences
Intracranial aneurysm (IA) is a life-threatening cerebrovascular disorder, the underlying molecular mechanisms of which remain incompletely elucidated. Pyroptosis, a pro-inflammatory form of programmed cell death, has been implicated in various vascular ...
Liu Yang, Cheng Yuanchi, Li Qian, Wang Delong   +3 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Caspase-3 western blot.

, 2022
Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410), Bernd Schmeck (334625), Hans-Helge Müller (158349), Thorsten Steinfeldt (9870476), Hinnerk Wulf (745052), Kerstin Seidel (385253), Wilhelm Bertrams (3172785), Marc-Alexander Oestreich (13961375)   +7 more
core   +1 more source

Acanthopagrus schlegelii FADD and caspase-8 are involved in the regulation of apoptosis and inflammation

Animal Advances
Acanthopagrus schlegelii is a farmed fish with significant economic value in China. Fas-associated protein with death domain (FADD) and caspase-8 are related to apoptosis and inflammation; however, the specific functions of FADD and caspase-8 in A ...
Jianlong Yang, Weishang Kong, Chuangchuang Wei, Xiaoqing Wang, Qian Meng, Chaofeng Jia, Zhiwei Zhang, Jiajia Li, Qingguo Meng   +8 more
doaj   +1 more source

Cyprinid Herpesvirus 2 miR-C12 Attenuates Virus-Mediated Apoptosis and Promotes Virus Propagation by Targeting Caspase 8

Frontiers in Microbiology, 2019
DNA viruses, most notably members of the herpesvirus family, generally encode miRNAs to mediate both virus and host genes expression. We previously demonstrated that Cyprinid herpesvirus 2 (CyHV-2) encodes 17 miRNAs that are involved in innate immune ...
Jianfei Lu, Jianfei Lu, Jianfei Lu, Zhaoyuan Shen, Zhaoyuan Shen, Zhaoyuan Shen, Liqun Lu, Liqun Lu, Liqun Lu, Dan Xu, Dan Xu, Dan Xu, Dan Xu   +12 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]

, 2003
Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B., Simon B. Brown, Brown, Simon B, Murray C.H. Clarke, David B. Jones, Savill, John, Brendon S. Noble, Clarke, Murray C H, Noble, Brendon S, John Savill   +9 more
core   +1 more source

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

EMBO Molecular Medicine, 2019
Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee   +9 more
doaj   +1 more source