Results 61 to 70 of about 307,642 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Cytotoxic Effects of Testosterone on Gastric Cancer Cell Line (AGS) and Evaluation of Caspase-3, -8, and -9 Activity

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Various studies have shown that sex steroids affect cancer cells at cellular and molecular level. In this study, the anti-proliferation effects of testosterone, was investigated on gastric cancer cell line (AGS) and activity ...
Neda Amani, Mehrdad Shariati, Rahim Ahmadi, Saeed Khatamsaz, Mokhtar Mokhtari   +4 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Effects of Ibuprofen Cytoxic Dose on caspase-3, -8 and -9 Activity level in cervical cancer (Hela) cells

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2019
BACKGROUND AND OBJECTIVE: Studies have shown that ibuprofen can have an anti-cancer effect on cervical cells, although the mechanism of this effect is not well known in cellular and molecular terms.
E Ghadiri, R Ahmadi, E Rostami
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer [PDF]

Gastric Cancer, 2011
Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.We undertook a case-control study of 88 GC cases and 480 controls to investigate the ...
Liamarkopoulos, E., Gazouli, M., Aravantinos, G., Tzanakis, N., Theodoropoulos, G., Rizos, S., Nikiteas, N.   +6 more
openaire   +3 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Assessment of apoptotic mediators in different periodontal plights: apoptosis markers in periodontal diseases

Dental Journal
Background: Highly expressed apoptosis markers in an inflammatory condition were observed following periodontal breakdown with obscure lineaments. Purpose: This trial aimed to assess the gingival crevicular fluid (GCF) level of caspase-3, -8, -9, and ...
Asem Mohammed Kamel Ali, Bahaa M. Badr, Abdullah I. Ali, Mohamoud A. Mizer, Ahmed M. Abdelrahman, Asmaa Rashad Ali, Abdel-Moneim M. I. Ghorab, Mohammed G. M. El Sherbeny, Azza A. Althoqapy   +8 more
doaj   +1 more source

Caspase-8 as a therapeutic target in cancer [PDF]

Cancer Letters, 2013
Caspase-8 is an apical caspase which initiates programmed cell death following death receptor ligation. This central role in apoptosis has prompted significant clinical interest in regulating caspase-8 expression and proteolytic activity. However, caspase-8 has also been found to play a number of non-apoptotic roles in cells, such as promoting ...
openaire   +2 more sources