Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun+15 more
wiley +1 more source
Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice. [PDF]
Pilot T+8 more
europepmc +1 more source
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
Claus Belka+9 more
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Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease [PDF]
Veena Viswanath+8 more
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This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li+9 more
wiley +1 more source
Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection [PDF]
Penny Clarke+4 more
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Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis+7 more
wiley +1 more source
Targeting caspase-8: a new strategy for combating hepatocellular carcinoma. [PDF]
Chen H+10 more
europepmc +1 more source
Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and Pyroptosis. [PDF]
Zheng Q+6 more
europepmc +1 more source