Results 181 to 190 of about 306,961 (215)

Caspase-8 in inflammatory diseases: a potential therapeutic target. [PDF]

Cell Mol Biol Lett
Zhang W, Zhu C, Liao Y, Zhou M, Xu W, Zou Z.   +5 more
europepmc   +1 more source

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration

Animal Models and Experimental Medicine, EarlyView.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +1 more source

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases. [PDF]

ACS Bio Med Chem Au
Bourne CM, Raniszewski NR, Mahale AB, Kulkarni M, Exconde PM, Liu S, Yost W, Wrong TJ, Patio RC, Kardhashi M, Shosanya T, Kambayashi M, Discher BM, Brodsky IE, Burslem GM, Taabazuing CY.   +15 more
europepmc   +1 more source

Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission. [PDF]

J Am Heart Assoc
Shimada K, Yamaguchi I, Miyamoto T, Korai M, Koyama H, Enomoto N, Shimabuku A, Kitazato KT, Kanematsu Y, Takagi Y.   +9 more
europepmc   +1 more source

Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy

Angewandte Chemie, EarlyView.
We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu, Yura Lee, Sanghee Yoon, Yun Wang, Yejin Cho, Seongyu Choi, Lu Lu, Hua Zhang, Sun Choi, Ki Taek Nam, Juyoung Yoon   +10 more
wiley   +1 more source

Evolutionary and Functional Analysis of Caspase-8 and ASC Interactions to Drive Lytic Cell Death, PANoptosis. [PDF]

Mol Biol Evol
Kumar SP, Nadendla EK, Malireddi RKS, Haque SA, Mall R, Neuwald AF, Kanneganti TD.   +6 more
europepmc   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +1 more source

<i>Staphylococcus aureus</i> reprograms CASP8 (caspase 8) signaling to evade cell death and Xenophagy. [PDF]

Autophagy
Ying YT, Yang J, Ye HW, Chen MY, Liu X, Chen W, Xu JX, Tan X.   +7 more
europepmc   +1 more source

FLIP_L permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization. [PDF]

Proc Natl Acad Sci U S A
Shaw JJP, Guy C, Tummers B, Green DR.
europepmc   +1 more source

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway. [PDF]

Invest Ophthalmol Vis Sci
Yang H, Liu M, Song S, Xu Q, Lee J, Sun J, Xue S, Sun X, Che C.   +8 more
europepmc   +1 more source