Results 21 to 30 of about 6,015,666 (337)
Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]
The FASEB Journal, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Alexandra K. Kiemer +9 more
openaire +4 more sources
Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]
Journal of Biological Chemistry, 2003 Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren +5 more
openaire +5 more sources
Caspase‐8 in Apoptosis: The Beginning of “The End”? [PDF]
IUBMB Life, 2000 AbstractCaspase‐8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase‐8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment into a multimeric complex or trans‐cleavage ...
Gerard I. Evan, Marieke Kruidering
openaire +3 more sources
Functions of caspase 8: The identified and the mysterious [PDF]
Seminars in Immunology, 2014 Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.
Salvesen, Guy S, Walsh, Craig M
openaire +6 more sources
Frontiers in Pharmacology, 2022 Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding +14 more
doaj +1 more source
Role of caspase-8 in thymus function [PDF]
Cell Death & Differentiation, 2013 The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition. During the developmental process, 98% of thymocytes die by apoptosis. Thus apoptosis is a dominant process in the thymus and occurs through either death by neglect or negative selection or through ...
POZZESI, NICOLA +6 more
openaire +3 more sources
Science Advances, 2020 Caspase-8–dependent GSDMD activation promotes antibacterial defense; however, this pathway can also mediate TNF shock in vivo. Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of proinflammatory cytokines. Recent studies
B. Demarco +13 more
semanticscholar +1 more source
Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity
Journal of Leukocyte Biology, 2020 Caspase‐8 is an apical caspase involved in the programmed form of cell death called apoptosis that is critically important for mammalian development and immunity.
Pontus Orning, E. Lien
semanticscholar +1 more source
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.
PLoS Pathogens, 2022 Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo +3 more
doaj +1 more source
The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
Brain Sciences, 2021 Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Zaara Liaquat +4 more
doaj +1 more source