Results 31 to 40 of about 307,642 (265)
Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source
FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Objective— To investigate the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated death domain–containing protein), caspase-3, and caspase-8, and incidence of coronary events (CEs) in a population-based cohort study.
Xue L +9 more
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Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 [PDF]
Journal of Biological Chemistry, 1998 The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that in a purified system, the initiator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km) of 8.7 x 10(5) and 2.8 x 10(5) M-1 s-1, respectively.
H R, Stennicke +13 more
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Frontiers in Pharmacology, 2022 Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding +14 more
doaj +1 more source
Frontiers in Oncology, 2019 Introduction: Definitive chemoradiation (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) represents state-of-the-art treatment for locally-advanced cervical cancer.
Max Fleischmann +25 more
doaj +1 more source
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.
PLoS Pathogens, 2022 Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo +3 more
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Cancer Research, 2008 Abstract Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor.
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Caspase‐8: regulating life and death [PDF]
Immunological Reviews, 2017 SummaryRoles for cell death in development, homeostasis, and the control of infections and cancer have long been recognized. Although excessive cell damage results in passive necrosis, cells can be triggered to engage molecular programs that result in cell death.
Bart Tummers, Douglas R. Green
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Role of caspase-8 in thymus function [PDF]
Cell Death & Differentiation, 2013 The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition. During the developmental process, 98% of thymocytes die by apoptosis. Thus apoptosis is a dominant process in the thymus and occurs through either death by neglect or negative selection or through ...
POZZESI, NICOLA +6 more
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Caspase‐8: not so silently deadly
Clinical & Translational Immunology, 2017 Apoptosis is a caspase‐dependent programmed form of cell death, which is commonly believed to be an immunologically silent process, required for mammalian development and maintenance of cellular homoeostasis. In contrast, lytic forms of cell death, such as RIPK3‐ and MLKL‐driven necroptosis, and caspase‐1/11‐dependent pyroptosis, are postulated to be ...
Feltham, R, Vince, JE, Lawlor, KE
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