Results 21 to 30 of about 307,642 (265)
The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
Brain Sciences, 2021 Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Zaara Liaquat +4 more
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Caspase‐8 in Apoptosis: The Beginning of “The End”? [PDF]
IUBMB Life, 2000 AbstractCaspase‐8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase‐8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment into a multimeric complex or trans‐cleavage ...
M, Kruidering, G I, Evan
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Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
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Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Teresa Ju +10 more
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Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang +4 more
doaj +1 more source
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Reports, 2020 Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos +6 more
doaj +1 more source
Molecules, 2020 Alzheimer’s disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is ...
Syed Sayeed Ahmad +4 more
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Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]
The FASEB Journal, 2005 ABSTRACT Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Blumenthal, Signe B. +8 more
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Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
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Unique and overlapping substrate specificities of caspase-8 and caspase-10 [PDF]
Oncogene, 2005 Although caspase-8 has an established role as an initiator of death receptor-mediated apoptosis, the function of its closest homolog, caspase-10, is almost completely unknown. To gain a closer insight into the physiological function of caspase-10, we compared the cleavage of known caspase-8 substrates by both initiator caspases.
U, Fischer, C, Stroh, K, Schulze-Osthoff
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