Results 31 to 40 of about 459,603 (305)
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. [PDF]
, 2007 Humans and mice lacking functional caspase-8 in T cells manifest a profound immunodeficiency syndrome due to defective T cell antigen receptor (TCR)-induced NF-kappaB signaling and proliferation.
Budd, R.C. +11 more
core +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano +30 more
core +3 more sources
Caspase-8 inhibition represses initial human monocyte activation in septic shock model [PDF]
, 2016 In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream phases.
Caballero-Velázquez, Teresa +10 more
core +2 more sources
Frontiers in Microbiology, 2022 Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others.
Raiany A. Santos +5 more
doaj +1 more source
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke [PDF]
, 2016 Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral macrophages, which contribute to an inflammatory response involved in ...
Burguillos García, Miguel Ángel +6 more
core +1 more source
TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Cell Death Discovery, 2023 Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu +9 more
doaj +1 more source
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis [PDF]
, 2009 Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when ...
Barbero, S +10 more
core +2 more sources
Cancer Research, 2008 Abstract Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor.
openaire +2 more sources
Caspase‐8: not so silently deadly
Clinical & Translational Immunology, 2017 Apoptosis is a caspase‐dependent programmed form of cell death, which is commonly believed to be an immunologically silent process, required for mammalian development and maintenance of cellular homoeostasis. In contrast, lytic forms of cell death, such as RIPK3‐ and MLKL‐driven necroptosis, and caspase‐1/11‐dependent pyroptosis, are postulated to be ...
Feltham, R, Vince, JE, Lawlor, KE
openaire +3 more sources
Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis
Galician Medical Journal, 2016 The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT).
M. I. Sheremet +3 more
doaj +1 more source