Results 31 to 40 of about 328,165 (224)
$Sp(8)$ invariant higher spin theory, twistors and geometric BRST formulation of unfolded field equations [PDF]
JHEP 0912:021,2009, 2009 We discuss twistor-like interpretation of the $Sp(8)$ invariant formulation of 4d massless fields in ten dimensional Lagrangian Grassmannian $Sp(8)/P$ which is the generalized space-time in this framework. The correspondence space $\mathbf{C}$ is $SpH(8)/PH$ where $SpH(8)$ is the semidirect product of $Sp(8)$ with Heisenberg group $\HG$ and $PH$ is ...
arxiv +1 more source
Cells, 2013 Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related diseases ...
Somkanya C Raychaudhuri +1 more
doaj +1 more source
Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. [PDF]
PLoS ONE, 2016 Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 ...
Jennifer Ly Tsang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Molecules, 2019 Caspase 8 is a central player in the apoptotic cell death pathway and is also essential for cytokine processing. The critical role of this protease in cell death pathways has generated research interest because its activation has also been linked with ...
Khurshid Ahmad +6 more
doaj +1 more source
Molecules, 2020 Alzheimer’s disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is ...
Syed Sayeed Ahmad +4 more
doaj +1 more source
Cell Death and Disease, 2021 Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Jia Xia +10 more
doaj +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018 Background and Objectives: Studies have shown that drugs can affect on proliferation of cancer cells. The main aim of this study was to determine the effects of diclofenac on caspase-8 and caspase-9 activity in cervical cancer cells (HeLa) in cell ...
Minoo Erfani +2 more
doaj
Molecular Therapy: Oncolytics, 2020 Human γδ T lymphocytes were reported to display anti-tumor effects against multiple cancers, including hepatocellular carcinoma (HCC). Aberrant expression of microRNAs (miRNAs) leads to a low response to immunotherapy.
Zhong Chen +9 more
doaj