Results 31 to 40 of about 6,015,666 (337)
Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
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Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
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Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
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Unique and overlapping substrate specificities of caspase-8 and caspase-10 [PDF]
Oncogene, 2005 Although caspase-8 has an established role as an initiator of death receptor-mediated apoptosis, the function of its closest homolog, caspase-10, is almost completely unknown. To gain a closer insight into the physiological function of caspase-10, we compared the cleavage of known caspase-8 substrates by both initiator caspases.
Christopher Stroh +2 more
openaire +3 more sources
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Science, 2018 Caspase-8 is a player in pyroptosis The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes.
Pontus Orning +17 more
semanticscholar +1 more source
The role of caspase-8 in the tumor microenvironment of ovarian cancer
Cancer metastasis reviews, 2020 Caspase-8 is an aspartate-specific cysteine protease, which is best known for its apoptotic functions. Caspase-8 is placed at central nodes of multiple signal pathways, regulating not only the cell cycle but also the invasive and metastatic cell behavior,
I. Kostova +3 more
semanticscholar +1 more source
Cancer Research, 2008 Abstract Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor.
openaire +3 more sources
Frontiers in Immunology, 2021 Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production.
Raksha Parthasarathy +9 more
doaj +1 more source
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Here we demonstrate that Yersinia YopJ-induced murine macrophage death involves caspase-8–induced cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME).
Joseph Sarhan +10 more
semanticscholar +1 more source
Frontiers in Oncology, 2019 Introduction: Definitive chemoradiation (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) represents state-of-the-art treatment for locally-advanced cervical cancer.
Max Fleischmann +25 more
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