Results 61 to 70 of about 328,165 (224)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Bistability preserving model reduction in apoptosis [PDF]
arXiv, 2007 Biological systems are typically very complex and need to be reduced before they are amenable to a thorough analysis. Also, they often possess functionally important dynamic features like bistability. In model reduction, it is sometimes more desirable to preserve the dynamic features only than to recover a good quantitative approximation. We present an
arxiv
From Binary Error Correcting Codes to a Relation Between Maximal D=4 and D=3 Supergravities [PDF]
arXiv, 2021 This short note provides (TensorFlow-based) numerical evidence for the embedability (in the limit of a scalar parameter going to infinity) of the scalar potential of dyonic N=8, D=4 SO(8) supergravity into the scalar potential of N=16, D=3 SO(8)xSO(8) supergravity.
arxiv
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Asymptotic Symmetry algebra of $\mathcal{N}=8$ Supergravity [PDF]
arXiv, 2022 The asymptotic symmetry algebra of $\mathcal{N}=1$ supergravity was recently constructed using the well-known $2$D celestial CFT (CCFT) technique in ArXiv: 2007.03785. In this paper, we extend the construction to the maximally supersymmetric four dimensional $\mathcal{N}=8$ supergravity theory in asymptotically flat spacetime and construct the extended
arxiv
Journal of Translational Autoimmunity, 2020 Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus.
Isabella Muscari +8 more
doaj
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells [PDF]
arXiv, 2007 We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells. This work is novel and is an extension on the recent reports and clarifications on the FAS apoptotic pathway from the literature.
arxiv
PB1755: CASPASE 8, CASPASE 10 AND FAS GENE POLYMORPHISMS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
HemaSphere, 2022 M. Lourou +6 more
doaj +1 more source
FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes
FEBS Open Bio, EarlyView.FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang +5 more
wiley +1 more source