Results 161 to 170 of about 274,382 (304)

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Evolutionarily Ancient Caspase-9 Sensitizes Immune Effector Coelomocytes to Cadmium-Induced Cell Death in the Sea Cucumber, Holothuria leucospilota. [PDF]

Front Immunol, 2022
Li X, Chen T, Wu X, Li Z, Zhang X, Jiang X, Luo P, Hu C, Wong NK, Ren C.   +9 more
europepmc   +1 more source

Regulation of Caspase-9 by Natural and Synthetic Inhibitors

, 2012
Tight regulation of caspase-9, a key initiator of apoptosis, is required to uphold cellular homeostasis. Although it is controlled on a multifactorial level, misregulation of this process does occur, which is a characteristic of a variety of diseases from ischemic injury to cancer.
openaire   +3 more sources

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway. [PDF]

Front Pharmacol, 2022
Huang R, Ding L, Ye Y, Wang K, Yu W, Yan B, Liu Z, Wang J.   +7 more
europepmc   +1 more source

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Genome-wide association studies identify the role of caspase-9 in kidney disease. [PDF]

Sci Adv, 2021
Doke T, Huang S, Huang S, Qiu C, Sheng X, Seasock M, Liu H, Ma Z, Palmer M, Susztak K.   +9 more
europepmc   +1 more source

Caspase-8 and Apaf-1-independent Caspase-9 Activation in Sendai Virus-infected Cells [PDF]

, 2002
Michael Bitzer, Sorin Armeanu, Florian Prinz, Guy Ungerechts, Wolfgang Wybranietz, Martin Spiegel, Christian Bernlöhr, Francesco Cecconi, Michael Gregor, Wolfgang J. Neubert, Klaus Schulze‐Osthoff, Ulrich M. Lauer   +11 more
openalex   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction. [PDF]

Front Immunol
Sternkopf LE, Prodjinotho UF, Gres V, Repgen N, Steiger K, Schluckebier J, Sikasunge CS, Stelzle D, Makasi C, Winkler AS, Ngowi BJ, Villalobos N, Ebner F, Häcker G, Henneke P, Prazeres da Costa C.   +15 more
europepmc   +1 more source