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Immunoregulatory Roles of Tumor‐Originated Pericytes Identified by Single‐Cell Analysis in Glioblastoma

Advanced Science, EarlyView.
The origin and functional heterogeneity of pericytes in glioblastoma (GBM) remain unclear. This study identifies tumor‐originated pericytes (T‐PCs) and normal‐originated pericytes as two distinctive populations in human GBM using single‐cell RNA‐sequencing.
Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu‐wu Bian, Hai‐bo Wu, Aili Zhang, Wenchao Zhou   +16 more
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Caspase-9 regulation: An update

Apoptosis, 2004
The complex sequence of events leading to apoptotic cell death is governed by an elaborate regulatory scheme involving the actions of both initiator and executioner proteases. Among the most intensively studied of the initiator caspases is caspase-9, an essential throughput element in the so-called intrinsic or mitochondrially gated pathway of ...
C. R. Johnson, W. D. Jarvis
openaire   +3 more sources

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

Nature Medicine, 2000
Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
Timothy S. Zheng, Stéphane Hunot, Donald W. Nicholson, Yuri Lazebnik, Richard A. Flavell, Takashi Momoi, Anu Srinivasan, Keisuke Kuida   +7 more
openaire   +3 more sources

Akt Phosphorylation Site Found in Human Caspase-9 Is Absent in Mouse Caspase-9

Biochemical and Biophysical Research Communications, 1999
Caspase-9 is one caspase upstream of caspase-3 and its activation is stimulated by Apaf-1/cytochrome c and inhibited by Akt signals. BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation. Recently, it was shown that human caspase-9 is phosphorylated by Akt and that its protease activity is reduced ...
Eriko Fujita, Takashi Momoi, Atsushi Jinbo, Hidenori Matuzaki, Hiroaki Konishi, Ushio Kikkawa   +5 more
openaire   +3 more sources

Caspase 9 is decreased in psoriatic epidermis

Acta Histochemica, 2006
Psoriasis is a proliferative and inflammatory disease of the skin. Caspase 9 is responsible for initiating the caspase activation cascade during apoptosis. Apoptosis is a physiological mechanism of homeostasis and development, and caspases are the executioners of apoptosis.
Oemeroglu, SUNA, Oeztas, MURAT ORHAN, Guerer, Mehmet Ali, Alli, Nuran, Oeztas, Pinar, Lortlar, Nese   +5 more
openaire   +4 more sources

Delineation of the caspase-9 signaling cascade

Apoptosis, 2007
In the intrinsic apoptosis pathway, mitochondrial disruption leads to the release of multiple apoptosis signaling molecules, triggering both caspase-dependent and -independent cell death. The release of cytochrome c induces the formation of the apoptosome, resulting in caspase-9 activation.
Jin Wang, Min Chen, Alan D. Guerrero
openaire   +3 more sources

Caspase-9

The International Journal of Biochemistry & Cell Biology, 2000
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
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Changes in Activities of Caspase-8 and Caspase-9 in Human Cervical Malignancy

International Journal of Gynecological Cancer, 2011
The apoptotic process of programmed cell death and its dysfunctions in a variety of human diseases, including cervical cancer, has become the focus of extensive scientific research. Caspases are considered key factors in the execution of apoptosis, although there are many aspects of their role to be elucidated.
Maria T. Ekonomopoulou, Maria Malandri, Zafiroula Iakovidou-Kritsi, Evaggelos Babas, Eleutheria Mioglou-Kalouptsi   +4 more
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Expression Analysis of caspase-6, caspase-9 and BNIP3 in Prostate Cancer

Tumori Journal, 2010
Aims Altered regulation of cell death is a feature of human cancer. The aim of this study was to explore whether the expression of the proapoptotic proteins caspase-6, caspase-9, and Bcl-2/adenovirus E1B-19kDa-interacting protein3 (BNIP3) is altered in prostate cancers.
Nam Jin Yoo, Min Seob Kim, Sug Hyung Lee, Sang Yong Song, Ji Youl Lee, Sang Wook Park, Seong Il Seo   +6 more
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Activation of Caspase-8 and Caspase-9 are Required for PC12 Cells Differentiation

Journal of Immunoassay and Immunochemistry, 2015
Nerve growth factor- (NGF) induced potent activation of caspase-8, and caspase-9 in PC12 cells in a time-dependent manner. Peptide inhibition of caspase activity led to a potent reduction in neurite outgrowth in NGF-treated cells. Although NGF treatment resulted in cell-cycle G0/G1 arrest as detected by FACS cell-cycle analysis, caspase inhibitors ...
Makio Mogi, Ayami Kondo
openaire   +3 more sources