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Expression of phosphorylated caspase‐9 in gastric carcinomas
APMIS, 2007Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Sug Hyung Lee +3 more
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Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes
Zygote, 2004The current consensus in the literature is that ovulated oocytes that are not fertilized die by apoptosis, but the details of the proteins involved in the apoptotic pathways have not been elucidated. In this paper we confirm that caspase-3, the executioner of apoptosis, is expressed in mouse oocytes, and show that two initiators of apoptosis, caspase-8
Donald M. O'Malley +3 more
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Caspase-9 as a therapeutic target for treating cancer
Expert Opinion on Therapeutic Targets, 2014Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee Kim +2 more
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Caspase 9: context-dependent killer
Trends in Cell Biology, 1998Abstract KUIDA, K. et al . (1998) Reduced apoptosis and cytochrome c -mediated caspase activation in mice lacking caspase 9 Cell 94, 325–337 Hakem, R. et al .
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The role of caspase‐8, caspase‐9, and apoptosis inducing factor in periodontal disease
Journal of Periodontology, 2018AbstractBackgroundCaspases are key mediators of apoptosis. Caspase‐8 mediates extrinsic, and caspase‐9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase‐independent process.
Yvonne L. Kapila +2 more
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Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Mar Royuela +7 more
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Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Mar Royuela +7 more
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Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway
Biochemical and Biophysical Research Communications, 2002C(2)-ceramide, a cell-permeable analog of ceramide, caused cell death in cultured rat cortical neuronal cells. C(2)-ceramide-induced neuronal loss was accompanied by upregulation of caspase-3 activity, measured by cleavage of its fluorogenic substrate Ac-DEVD-AMC.
Vilen A. Movsesyan +4 more
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Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts
Journal of Molecular Histology, 2008Development of new therapies for glioblastoma requires animal models that mimic the biological characteristics of human brain tumors. On the other hand, potential antitumoral effects of a new therapeutic strategy are often established by evaluation of tumor cells apoptosis.
Mihaela Chivu +3 more
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Expression of caspase‐8 and caspase‐9 in rat hippocampus during postnatal development
Microscopy Research and Technique, 2011AbstractThe role of caspases in the regulation of apoptosis of neurons during development is well established. An emerging body of evidence indicates that caspases may also play significant roles which are nonapoptotic. We have demonstrated previously that the executor caspase‐3 exhibited a unique pattern of spatiotemporal expression in the postnatal ...
Tao Lu +6 more
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Caspase‐3 and caspase‐9 mediate developmental apoptosis in the mouse olfactory system
Journal of Comparative Neurology, 2004AbstractNeuronal apoptosis is a key component in the sculpting of tissues during embryonic and postnatal development and is driven largely by the action of caspases. In the mouse olfactory system, caspase‐3 and ‐9 are expressed in olfactory receptor neurons (ORNs) of adult mice, and their selective retrograde activation drives ORN apoptosis following ...
A. Jane Roskams, Catherine M. Cowan
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