Results 21 to 30 of about 294,959 (259)

Caspase-9 and effector caspases have sequential and distinct effects on mitochondria [PDF]

Oncogene, 2005
Proapoptotic Bcl-2 family members alter mitochondrial permeability resulting in the release of apoptogenic factors that initiate a caspase cascade. These changes are well described; however, the effects of caspases on mitochondrial function are less well characterized.
Enrique, Cepero, Anne M, King, Lane M, Coffey, Rebeka G, Perez, Lawrence H, Boise   +4 more
openaire   +2 more sources

MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin

浙江大学学报. 农业与生命科学版, 2012
To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen, ZHANG Xiao-yuan, SUN Fen-yong, GUO Yong   +3 more
doaj   +1 more source

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]

Journal of Biological Chemistry, 2003
The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Hua, Zou, Ruomei, Yang, Junshan, Hao, Jean, Wang, Chaohong, Sun, Stephen W, Fesik, Joe C, Wu, Kevin J, Tomaselli, Robert C, Armstrong   +8 more
openaire   +2 more sources

Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer [PDF]

Gastric Cancer, 2011
Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.We undertook a case-control study of 88 GC cases and 480 controls to investigate the ...
Liamarkopoulos, E., Gazouli, M., Aravantinos, G., Tzanakis, N., Theodoropoulos, G., Rizos, S., Nikiteas, N.   +6 more
openaire   +3 more sources

Bcl-2, active caspase-9 and inactive caspase-9 levels as markers of apoptosis in the serum and tissue of vitiligo patients

Al-Azhar Assiut Medical Journal, 2017
Background Vitiligo is the most common depigmentation disorder of the skin. It is considered a multifactorial disorder. However, its exact etiology is unknown.
Eman R.M Hofny, Howayda I Hasan, Nahed A Mohamed, Maysaa S Bamatraf, Ayman M.M Mahran   +4 more
doaj   +1 more source

Characterization of a Novel Proapoptotic Caspase-2- and Caspase-9-binding Protein [PDF]

Journal of Biological Chemistry, 2001
Caspases play important roles in regulating apoptotic signaling pathways. Here we report the cloning, by the yeast two hybrid system with dominant negative caspase-2 as "bait," of a proapoptotic molecule named proapoptotic caspase adaptor protein (PACAP), encoded by a 372-base pair open reading frame. Binding of this novel protein to caspase-2 (casp-2)
E, Bonfoco, E, Li, F, Kolbinger, N R, Cooper   +3 more
openaire   +2 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang, Whika Febria Dewatisari, Andina Setyawati, Risma Dumiri Manurung, Eka Setiawan   +4 more
doaj   +1 more source

Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation [PDF]

The FEBS Journal, 2009
Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase‐9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
Allan, Lindsey A., Clarke, Paul R.
openaire   +5 more sources

Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation

مجله دانشگاه علوم پزشکی بیرجند, 2023
Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin, Armin Derakhshideh, Mohammad Ali Azarbayjani, Nasrin Hosseini   +3 more
doaj